Search

Search results

• "Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction", Schupfner, Straub, Busch, Merkl, Sterner, 2019

  Publication

  Tryptophan synthase (TS) is a heterotetrameric alpha beta beta alpha complex. It is characterized by the channeling of the reaction intermediate...

  Publication on epub.uni-regensburg.de: "Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction" (external link, opens in a new window)

• "Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint", Schupfner, Busch, Wysocki, Sterner, 2019

  Publication

  The alpha beta beta alpha tryptophan synthase (TS), which is part of primary metabolism, is a paradigm for allosteric communication in multienzyme...

  Publication on epub.uni-regensburg.de: "Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint" (external link, opens in a new window)

• "Prediction of quaternary structure by analysis of hot spot residues in protein‐protein interfaces: the case of anthranilate phosphoribosyltransferases", Schlee, Straub, Schwab, Kinateder, Merkl, Sterner, 2019

  Publication

  It is an important goal of computational biology to correctly predict the association state of a protein based on its amino acid sequence and the...

  Publication on epub.uni-regensburg.de: "Prediction of quaternary structure by analysis of hot spot residues in protein‐protein interfaces: the case of anthranilate phosphoribosyltransferases" (external link, opens in a new window)

• "Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids", Kneuttinger, Straub, Bittner, Simeth, Bruckmann, Busch, Rajendran, Hupfeld, Wysocki, Horinek, König, Merkl, Sterner, 2019

  Publication

  Imidazole glycerol phosphate synthase (ImGPS) is an allosteric bienzyme complex in which substrate binding to the synthase subunit HisF stimulates the...

  Publication on epub.uni-regensburg.de: "Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids" (external link, opens in a new window)

• "Photochromic Coenzyme Q Derivatives: Switching Redox Potentials with Light", Simeth, Kneuttinger, Sterner, König, 2017

  Publication

  Coenzyme Q is an important redox cofactor involved in a variety of cellular processes, and thus found in several cell compartments. We report a...

  Publication on epub.uni-regensburg.de: "Photochromic Coenzyme Q Derivatives: Switching Redox Potentials with Light" (external link, opens in a new window)

• "Evolutionary diversification of protein–protein interactions by interface add-ons", Plach, Semmelmann, Busch, Busch, Heizinger, Wysocki, Merkl, Sterner, 2017

  Publication

  Cells contain amultitude of protein complexes whose subunits interact with high specificity. However, the number of different protein folds and...

  Publication on epub.uni-regensburg.de: "Evolutionary diversification of protein–protein interactions by interface add-ons" (external link, opens in a new window)

• "Combining ancestral sequence reconstruction with protein design to identify an interface hotspot in a key metabolic enzyme complex", Holinski, Heyn, Merkl, Sterner, 2017

  Publication

  It is important to identify hotspot residues that determine protein-protein interactions in interfaces of macromolecular complexes. We have applied a...

  Publication on epub.uni-regensburg.de: "Combining ancestral sequence reconstruction with protein design to identify an interface hotspot in a key metabolic enzyme complex" (external link, opens in a new window)

• "Diversity of bacteria and archaea from two shallow marine hydrothermal vents from Vulcano Island", Antranikian, Suleiman, Schäfers, Adams, Bartolucci, Blamey, Birkeland, Bonch-Osmolovskaya, da Costa, Cowan, Danson, Forterre, Kelly, Ishino, Littlechild, Moracci, Noll, Oshima, Robb, Rossi, Santos, Schönheit, Sterner, Thauer, Thomm, Wiegel, Stetter, 2017

  Publication

  To obtain new insights into community compositions of hyperthermophilic microorganisms, defined as having optimal growth temperatures of 80 degrees C...

  Publication on epub.uni-regensburg.de: "Diversity of bacteria and archaea from two shallow marine hydrothermal vents from Vulcano Island" (external link, opens in a new window)

• "In Silico Identification and Experimental Validation of Distal Activity-Enhancing Mutations in Tryptophan Synthase", Maria-Solano, Kinateder, Iglesias-Fernández, Sterner, Osuna, 2021

  Publication

  Allostery is a central mechanism for the regulation of multi-enzyme complexes. The mechanistic basis that drives allosteric regulation is poorly...

  Publication on epub.uni-regensburg.de: "In Silico Identification and Experimental Validation of Distal Activity-Enhancing Mutations in Tryptophan Synthase" (external link, opens in a new window)

• "Reprogramming the Specificity of a Protein Interface by Computational and Data-Driven Design", Hertle, Nazet, Semmelmann, Schlee, Funke, Merkl, Sterner, 2021

  Publication

  The formation of specific protein complexes in a cell is a non-trivial problem given the co-existence of thousands of different polypeptide chains. A...

  Publication on epub.uni-regensburg.de: "Reprogramming the Specificity of a Protein Interface by Computational and Data-Driven Design" (external link, opens in a new window)