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Publikationen der AG Molekulare Psychopharmakologie


Ausgewählte Publikationen

  • Brunner LM, Maurer F, Weber K, Weigl J, Milenkovic VM, Rupprecht R, Nothdurfter C, Mühlberger A.Differential effects of the translocator protein 18 kDa (TSPO) ligand etifoxine and the benzodiazepine alprazolam on startle response to predictable threat in a NPU-threat task after acute and short-term treatment. Psychopharmacology (Berl). 2022 Jul;239(7):2233-2244. doi: 10.1007/s00213-022-06111-x. Epub 2022 Mar 12. PMID: 35278124

  • Bauer O, Milenkovic VM, Hilbert S, Sarubin N, Weigl J, Bahr LM, Wetter TC, Heckel B, Wetzel CH, Rupprecht R, Nothdurfter C.Association of Chemokine (C-C Motif) Receptor 5 and Ligand 5 with Recovery from Major Depressive Disorder and Related Neurocognitive Impairment. Neuroimmunomodulation. 2020;27(3):152-162. doi: 10.1159/000513093. Epub 2021 Jan 27. PMID: 33503626

  • Bahr LM, Maurer F, Weigl J, Weber K, Melchner D, Dörfelt A, Wechsler TF, Bauer O, Reinders J, Milenkovic VM, Wetzel CH, Wetter TC, Rupprecht R, Mühlberger A, Nothdurfter C. Dissociation of endocrine responses to the Trier Social Stress Test in Virtual Reality (VR-TSST) by the benzodiazepine alprazolam and the translocator protein 18 kDa (TSPO) ligand etifoxine. Psychoneuroendocrinology. 2021 Feb;124:105100. doi: 10.1016/j.psyneuen.2020.105100. Epub 2020 Dec 5.

  • Sarubin N, Hilbert S, Naumann F, Zill P, Wimmer AM, Nothdurfter C, Rupprecht R, Baghai TC, Bühner M, Schüle C. The sex-dependent role of the glucocorticoid receptor in depression: variations in the NR3C1 gene are associated with major depressive disorder in women but not in men. Eur Arch Psychiatry Clin Neurosci. 2017;267:123-133.
  • Nothdurfter C, Milenkovic VM, Sarubin N, Hilbert S, Manook A, Weigl J, Almeqbaali K, Wetzel CH, Rupprecht R, Baghai TC. The cytokine IL-17A as a marker of treatment resistance in major depressive disorder? Eur J Neurosci. 2019 Dec 2. doi: 10.1111/ejn.14636. Online ahead of print.
  • Baghai TC, Varallo-Bedarida G, Born C, Häfner S, Schüle C, Eser D, Zill P, Manook A, Weigl J, Jooyandeh S, Nothdurfter C, von Schacky C, Bondy B, Rupprecht R. Classical Risk Factors and Inflammatory Biomarkers: One of the Missing Biological Links between Cardiovascular Disease and Major Depressive Disorder. Int J Mol Sci. 2018 Jun 12;19(6).
  • Bader S, Wolf L, Milenkovic VM, Gruber M, Nothdurfter C, Rupprecht R, Wetzel CH. Differential effects of TSPO ligands on mitochondrial function in mouse microglia cells. Psychoneuroendocrinology. 2019;106:65-76.
  • Milenkovic VM, Slim D, Bader S, Koch V, Heinl ES, Alvarez-Carbonell D, Nothdurfter C, Rupprecht R, Wetzel CH. CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells. Int J Mol Sci. 2019;20(13):3359.
  • Kuffner K, Triebelhorn J, Meindl K, Benner C, Manook A, Sudria-Lopez D, Siebert R, Nothdurfter C, Baghai TC, Drexler K, Berneburg M, Rupprecht R, Milenkovic VM, Wetzel CH. Major Depressive Disorder is Associated with Impaired Mitochondrial Function in Skin Fibroblasts. Cells. 2020;9(4):884.
  • Milenkovic VM, Bader S, Sudria-Lopez D, Siebert R, Brandl C, Nothdurfter C, Weber BHF, Rupprecht R, Wetzel CH. Effects of genetic variants in the TSPO gene on protein structure and stability. PLoS One. 2018 Apr 11;13(4):e0195627. PMID: 29641545 Free PMC Article
  • Milenkovic VM, Sarubin N, Hilbert S, Baghai TC, Stöffler F, Lima-Ojeda JM, Manook A, Almeqbaali K, Wetzel CH, Rupprecht R, Nothdurfter C. Macrophage-Derived Chemokine: A Putative Marker of Pharmacological Therapy Response in Major Depression? Neuroimmunomodulation. 2017;24(2):106-112. doi: 10.1159/000479739. Epub 2017 Sep 13. PMID: 28898872
  • Sarubin N, Baghai TC, Lima-Ojeda JM, Melchner D, Hallof-Buestrich H, Wolf L, Hilbert S, Milenkovic VM, Wetzel CH, Rupprecht R, Nothdurfter C. Translocator Protein (TSPO) Expression in Platelets of Depressed Patients Decreases during Antidepressant Therapy. Pharmacopsychiatry. 2016 Sep;49(5):204-209. PMID: 27276366
  • Wolf L, Bauer A, Melchner D, Hallof-Buestrich H, Stoertebecker P, Haen E, Kreutz M, Sarubin N, Milenkovic VM, Wetzel CH, Rupprecht R, Nothdurfter C. Enhancing neurosteroid synthesis--relationship to the pharmacology of translocator protein (18 kDa) (TSPO) ligands and benzodiazepines. Pharmacopsychiatry. 2015 Mar;48(2):72-7. doi: 10.1055/s-0034-1398507. PMID: 25654303
  • Nothdurfter C, Schmotz C, Sarubin N, Baghai TC, Laenger A, Lieb M, Bondy B, Rupprecht R, Schüle C. Effects of escitalopram/quetiapine combination therapy versus escitalopram monotherapy on hypothalamic-pituitary-adrenal-axis activity in relation to antidepressant effectiveness. J Psychiatr Res. 2014 May;52:15-20. doi: 10.1016/j.jpsychires.2014.01.013.PMID: 24513501
  • Nothdurfter C, Tanasic S, Di Benedetto B, Uhr M, Wagner EM, Gilling KE, Parsons CG, Rein T, Holsboer F, Rupprecht R, Rammes G. Lipid raft integrity affects GABAA receptor, but not NMDA receptor modulation by psychopharmacological compounds. Int J Neuropsychopharmacol. 2012 Dec 10:1-11. [Epub ahead of print] PMID: 23217923
  • Nothdurfter C, Baghai TC, Schüle C, Rupprecht R. Translocator protein (18 kDa) (TSPO) as a therapeutic target for anxiety and neurologic disorders. Eur Arch Psychiatry Clin Neurosci. 2012 Nov;262 Suppl 2:S107-12. doi: 10.1007/s00406-012-0352-5. Epub 2012 Aug 26. Review. PMID: 22923187
  • Nothdurfter C, Giegling I, Konte B, Hartmann AM, Konnerth H, Friedl M, Rammes G, Rupprecht R, Rujescu D. Lack of association of the 5-HT(3A) receptor with schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2012 Apr;159B(3):310-5. doi: 10.1002/ajmg.b.32028. Epub 2012 Feb 10. PMID: 22328445
  • Nothdurfter C, Rupprecht R, Rammes G. Recent developments in potential anxiolytic agents targeting GABAA/BzR complex or the translocator protein (18kDa) (TSPO). Curr Top Med Chem. 2012;12(4):360-70. Review. PMID: 22204486
  • Di Benedetto B, Kühn R, Nothdurfter C, Rein T, Wurst W, Rupprecht R. N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant. Neuropharmacology. 2012 Jan;62(1):209-16. doi: 10.1016/j.neuropharm.2011.07.001. Epub 2011 Jul 13. PMID: 21767553
  • Nothdurfter C, Rammes G, Baghai TC, Schüle C, Schumacher M, Papadopoulos V, Rupprecht R. Translocator protein (18 kDa) as a target for novel anxiolytics with a favourable side-effect profile. J Neuroendocrinol. 2012 Jan;24(1):82-92. doi: 10.1111/j.1365-2826.2011.02166.x. Review. PMID: 21609361
  • Nothdurfter C, Tanasic S, Rammes G, Rupprecht R. Modulation of ligand-gated ion channels as a novel pharmacological principle. Pharmacopsychiatry. 2011 May;44 Suppl 1:S27-34. doi: 10.1055/s-0031-1271704. Epub 2011 May 4. PMID: 21544743
  • Schüle C, Eser D, Baghai TC, Nothdurfter C, Kessler JS, Rupprecht R. Neuroactive steroids in affective disorders: target for novel antidepressant or anxiolytic drugs? Neuroscience. 2011 Sep 15;191:55-77. doi: 10.1016/j.neuroscience.2011.03.025. Epub 2011 Mar 23. Review. PMID: 21439354
  • Nothdurfter C, Tanasic S, Di Benedetto B, Rammes G, Wagner EM, Kirmeier T, Ganal V, Kessler JS, Rein T, Holsboer F, Rupprecht R. Impact of lipid raft integrity on 5-HT3 receptor function and its modulation by antidepressants. Neuropsychopharmacology. 2010 Jun;35(7):1510-9. doi: 10.1038/npp.2010.20. Epub 2010 Mar 3. PMID: 20200506
  • Zwanzger P, Eser D, Nothdurfter C, Baghai TC, Möller HJ, Padberg F, Rupprecht R. Effects of the GABA-reuptake inhibitor tiagabine on panic and anxiety in patients with panic disorder. Pharmacopsychiatry. 2009 Nov;42(6):266-9. doi: 10.1055/s-0029-1241798. Epub 2009 Nov 18. PMID: 19924586
  • Rammes G, Hosp C, Eisensamer B, Tanasic S, Nothdurfter C, Zieglgänsberger W, Rupprecht R. Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors. PLoS One. 2009 Aug 21;4(8):e6715. doi: 10.1371/journal.pone.0006715. PMID: 19696922
  • Rupprecht R, Rammes G, Eser D, Baghai TC, Schüle C, Nothdurfter C, Troxler T, Gentsch C, Kalkman HO, Chaperon F, Uzunov V, McAllister KH, Bertaina-Anglade V, La Rochelle CD, Tuerck D, Floesser A, Kiese B, Schumacher M, Landgraf R, Holsboer F, Kucher K. Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. Science. 2009 Jul 24;325(5939):490-3. doi: 10.1126/science.1175055. Epub 2009 Jun 18. Erratum in: Science. 2009 Aug 28;325(5944):1072. Dosage error in article text.  PMID: 19541954
  • Eser D, Nothdurfter C, Schüle C, Damm J, Steng Y, Möller HJ, Rupprecht R, Baghai T. The influence of anaesthetic medication on safety, tolerability and clinical effectiveness of electroconvulsive therapy. World J Biol Psychiatry. 2010 Mar;11(2 Pt 2):447-56. doi: 10.1080/15622970902960897. PMID: 19462341
  • Eser D, Baghai TC, Schüle C, Nothdurfter C, Rupprecht R. Neuroactive steroids as endogenous modulators of anxiety. Curr Pharm Des. 2008;14(33):3525-33. Review. PMID: 19075729
  • Schüle C, Baghai TC, Eser D, Nothdurfter C, Rupprecht R. Lithium but not carbamazepine augments antidepressant efficacy of mirtazapine in unipolar depression: an open-label study. World J Biol Psychiatry. 2009;10(4 Pt 2):390-9. doi: 10.1080/15622970701849978. PMID: 18609420
  • Eser D, Leicht G, Baghai T, Pogarell O, Schüle C, Karch S, Nothdurfter C, Rupprecht R, Mulert C. Impact of loudness dependency of auditory evoked potentials on the panic response to CCK-4. J Psychiatr Res. 2009 Jan;43(4):393-400. doi: 10.1016/j.jpsychires.2008.04.010. Epub 2008 Jun 4. PMID: 18534623
  • Nothdurfter C. [The diagnosis is cancer--and then depression?]. MMW Fortschr Med. 2007 Apr 19;149(16):27-30. Review. German. PMID: 17953260
  • Nothdurfter C, Rammes G, Rein T, Rupprecht R. Pitfalls in isolating lipid rafts. Nat Rev Neurosci. 2007;8:567.   
  • Schüle C, Baghai TC, Eser D, Hecht S, Hermisson I, Born C, Häfner S, Nothdurfter C, Rupprecht R. Mirtazapine monotherapy versus combination therapy with mirtazapine and aripiprazole in depressed patients without psychotic features: a 4-week open-label parallel-group study. World J Biol Psychiatry. 2007;8(2):112-22. PMID:17455104
  • Baghai TC, Binder EB, Schule C, Salyakina D, Eser D, Lucae S, Zwanzger P, Haberger C, Zill P, Ising M, Deiml T, Uhr M, Illig T, Wichmann HE, Modell S, Nothdurfter C, Holsboer F, Müller-Myhsok B, Möller HJ, Rupprecht R, Bondy B. Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism. Mol Psychiatry. 2006 Nov;11(11):1003-15. Epub 2006 Aug 22. PMID: 16924268
  • Nothdurfter C, Eser D, Schüle C, Zwanzger P, Marcuse A, Noack I, Möller HJ, Rupprecht R, Baghai TC. The influence of concomitant neuroleptic medication on safety, tolerability and clinical effectiveness of electroconvulsive therapy. World J Biol Psychiatry. 2006;7(3):162-70. PMID: 16861142
  • Baghai TC, Marcuse A, Brosch M, Schüle C, Eser D, Nothdurfter C, Steng Y, Noack I, Pietschmann K, Möller HJ, Rupprecht R. The influence of concomitant antidepressant medication on safety, tolerability and clinical effectiveness of electroconvulsive therapy. World J Biol Psychiatry. 2006;7(2):82-90. PMID: 16684680
  • Stübner S, Nothdurfter C, Grohmann R, Eckermann G. SIADH unter Citalopram in Kombination mit Omeprazol, Metoprolol und Ramipril. Psychopharmakotherapie. 2005;12/5, 195-197.

  1. Fakultät für Medizin
  2. Lehrstühle und Abteilungen

Molekulare Psychopharmakologie

Prof. Dr. med. habil.

Caroline Nothdurfter


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