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• "Dimerization determines substrate specificity of a bacterial prenyltransferase", Peterhoff, Zellner, Guldan, Merkl, Sterner, Babinger, 2012

  Publication

  We have identified the native dimer interface of heptaprenylglyceryl phosphate synthase PcrB from the bacterium Bacillus subtilis and analyzed the...

  Publication on epub.uni-regensburg.de: "Dimerization determines substrate specificity of a bacterial prenyltransferase" (external link, opens in a new window)

• "Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site", List, Vega, Razeto, Häger, Sterner, Wilmanns, 2012

  Publication

  Nitrogen is incorporated into various metabolites by multifunctional glutamine amidotransferases via reactive ammonia generated by glutaminase...

  Publication on epub.uni-regensburg.de: "Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site" (external link, opens in a new window)

• "Constitutively Active Glutaminase Variants Provide Insights into the Activation Mechanism of Anthranilate Synthase", List, Bocola, Haeger, Sterner, 2012

  Publication

  The glutamine amidotransferase (GATase) family comprises enzyme complexes which consist of glutaminase and synthase subunits that catalyze in a...

  Publication on epub.uni-regensburg.de: "Constitutively Active Glutaminase Variants Provide Insights into the Activation Mechanism of Anthranilate Synthase" (external link, opens in a new window)

• "Directed evolution of ( )8-barrel enzymes: establishing phosphoribosylanthranilate isomerisation activity on the scaffold of the tryptophan synthase -subunit", Evran, Telefoncu, Sterner, 2012

  Publication

  Phosphoribosylanthranilate (PRA) isomerase (TrpF) and tryptophan synthase -subunit (TrpA) are ()(8)-barrel enzymes that are involved in the...

  Publication on epub.uni-regensburg.de: "Directed evolution of ( )8-barrel enzymes: establishing phosphoribosylanthranilate isomerisation activity on the scaffold of the tryptophan synthase -subunit" (external link, opens in a new window)

• "Random mutagenesis suggests that sequence errors are not a major cause of variation in the activity of individual molecules of β-galactosidase", Craig, Schwab, Sterner, 2012

  Publication

  Wild-type Escherichia coli lacZ was subjected to error-prone PCR to generate two plasmid-encoded gene libraries containing approximately 2.6 (SD 1.9)...

  Publication on epub.uni-regensburg.de: "Random mutagenesis suggests that sequence errors are not a major cause of variation in the activity of individual molecules of β-galactosidase" (external link, opens in a new window)

• "Folding Mechanism of an Extremely Thermostable (βα)8-Barrel Enzyme: A High Kinetic Barrier Protects the Protein from Denaturation", Carstensen, Zoldák, Schmid, Sterner, 2012

  Publication

  HisF, the cyclase subunit of imidazole glycerol phosphate synthase (ImGPS) from Thermotoga maritima, is an extremely thermostable (beta...

  Publication on epub.uni-regensburg.de: "Folding Mechanism of an Extremely Thermostable (βα)8-Barrel Enzyme: A High Kinetic Barrier Protects the Protein from Denaturation" (external link, opens in a new window)

• "Conservation of the Folding Mechanism between Designed Primordial (βα)8-Barrel Proteins and Their Modern Descendant", Carstensen, Sperl, Bocola, List, Schmid, Sterner, 2012

  Publication

  The (beta alpha)(8)-barrel is among the most ancient, frequent, and versatile enzyme structures. It was proposed that modern (beta alpha)(8)-barrel...

  Publication on epub.uni-regensburg.de: "Conservation of the Folding Mechanism between Designed Primordial (βα)8-Barrel Proteins and Their Modern Descendant" (external link, opens in a new window)

• "Experimental assessment of the importance of amino acid positions identified by an entropy-based correlation analysis of multiple sequence alignments", Dietrich, Borst, Schlee, Schneider, Janda, Sterner, Merkl, 2012

  Publication

  The analysis of a multiple-sequence alignment (MSA) with correlation methods identifies pairs of residue positions whose occupation with amino acids...

  Publication on epub.uni-regensburg.de: "Experimental assessment of the importance of amino acid positions identified by an entropy-based correlation analysis of multiple sequence alignments" (external link, opens in a new window)

• "Establishing catalytic activity on an artificial (βα)8‐barrel protein designed from identical half‐barrels", Sperl, Rohweder, Rajendran, Sterner, 2013

  Publication

  It has been postulated that the ubiquitous (beta alpha)(8)-barrel enzyme fold has evolved by duplication and fusion of an ancestral (beta...

  Publication on epub.uni-regensburg.de: "Establishing catalytic activity on an artificial (βα)8‐barrel protein designed from identical half‐barrels" (external link, opens in a new window)

• "Kinetic Mechanism of Indole-3-glycerol Phosphate Synthase", Schlee, Dietrich, Kurćon, Delaney, Goodey, Sterner, 2013

  Publication

  The (beta alpha)(8)-barrel enzyme indole-3-glycerol phosphate synthase (IGPS) catalyzes the multistep transformation of...

  Publication on epub.uni-regensburg.de: "Kinetic Mechanism of Indole-3-glycerol Phosphate Synthase" (external link, opens in a new window)