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Genetics

Focus Subject - Genetics

You have to choose the theoretical module and one practical module.

TM  Theoretical Module (12 CP)

Genetics

Prof. Dr. Wolfgang Seufert, Prof. Dr. Frank Sprenger

PM  Practical Modules (12 CP each)

Regulation of Cell Division and mRNA Translation Prof. Dr. Wolfgang Seufert
Regulation of Cell Division in Drosophila Prof. Dr. Frank Sprenger
Post-transcriptional regulation of gene expression (link) PD Dr. Jan Medenbach

Registration

Please contact Prof. Seufert (wolfgang.seufert@ur.de) or Prof. Sprenger (frank.sprenger@ur.de), respectively, for application to the practical modules of the Focus Subject. There will be an introductory session for all interested students on Thursday, October 18, 2018 at 09:00 Uhr in DE_1.113.


TM Genetics

BIO-M-TM-G

Detailed module description - pdf

Prof. Dr. Wolfgang Seufert, Prof. Dr. Frank Sprenger

Module contents
  • Cell Cycle: common regulatory mechanisms in the control of the cell cycle, DNA-replication, DNA-damage response, mitosis, meiosis, cytokinesis.
  • Translation: Regulation of translation of eucaryotic mRNAs
  • Presentation and discussion of a research based topic from the topics listed above
  • Elaboration and presentation of methods that are used in cell cycle and translational control
Module components
  1. lecture: Cell Cycle Control in Eucaryotes / Control of Cell Proliferation
  2. seminar: Methods in Cell Cycle and Translation Control / a lecture in the field of genetics or molecular or cellular biology (for a selection see LSF)
  3. seminar: Seminar on Current Topics in Cell Cycle and Translation Control / Cell Proliferation Control

In the seminar No. 3 a seminar presentation has to be held and registered in Flexnow as an ungraded study achievement (Studienleistung).

Module examination

30 min oral examination (graded)

The student can choose the examiner.

(Der Prüfer kann vom Studierenden frei gewählt werden.)


PM Regulation of Cell Division and mRNA Translation

BIO-M-PM-CDT

Detailed module description - pdf

Prof. Dr. Wolfgang Seufert (link to research group)

Application for practical Module in the lab of Wolfgang Seufert for WS18/19 and SS 19: Please download this form and send it back to Wolfgang Seufert

Application for practical Module in the lab of Jan Medenbach for WS18/19 and SS 19: Please download this form and send it back to Jan Medenbach

Module contents
  • Analysis of the cell division cycle in budding yeast by use of classical genetic techniques such as mating, sporulation and tetrade dissection as well as cell synchronization, confocal fluorescence microscopy, time-lapse live-cell imaging, flow cytometry and further methods
  • Analysis of the assembly of eIF2 by Cdc123 using PCR-mediated epitope-tagging, Western analysis, co-immunoprecipitation, yeast two-hybrid assays, heterologous expression and affinity-purification of proteins, ThermoFluor analysis and further methods
  • Analysis of the control of mRNA translation by gene reporter assays, RNA preparation, RT-qPCR and RNAseq analysis, polysome profiling and further methods
  • Presentation and discussion of own experimental gained data
Module components

Laboratory course (6 weeks) with seminar: Regulation of Cell Division and mRNA Translation

Module examination

Portfolio examination (graded)


PM Regulation of Cell Division in Drosophila

BIO-M-PM-CDD

Detailed module description - pdf

Prof. Dr. Frank Sprenger (link to research group)

Application for WS18/19 and SS 19: Please downlods this form and send it back to Prof.Sprenger

Module contents

In a six-week research project the student will work under guidance on a current research topics in the field of cell cycle regulatory processes. He will use, among other things, tissue culture cells (from Drosophila and vertebrates) as well as different developmental stages from Drosophila.

The student will present and discuss the data obtained in the research project as well as the relevant scientific background in a written report and will present and discuss the results in an oral presentation.

Module components

Laboratory course (6 weeks) with seminar: Regulation of Cell Division in Drosophila

Module examination

Portfolio examination (graded)

  1. Fakultät für Biologie und Vorklinische Medizin
  2. Studium