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Sombuddha Sengupta, Rajat Mukherjee, Michael Pilsl, Siddharam Bagale, Arijit das Adhikary, Aditi N. Borkar, Pushpangadan Indira Pradeepkumar, Christoph Engel, … and Ruchi Anand

Mechanistic insights into 50S precursor recognition and targeting by erythromycin resistance methyltransferase (externer Link, öffnet neues Fenster)

Science Advances, Volume 11, Issue 48, DOI: 10.1126, 2025


Gunnar Mair, Julia L. Daiß, Christoph Engel$ und Konstantin I Panov$

The ribosomal RNA transcription landscapes of Plasmodium falciparum und related apicomplexan parasites (externer Link, öffnet neues Fenster)

Nucleic Acids Research, Volume 53, Issue 13, 2025


Daniela Tarau, Felix Grünberger, Michael Pilsl, Robert Reichelt, Florian Heiß, Sabine König, Henning Urlaub, Winfried Hausner, Christoph Engel$ und Dina Grohmann$

Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment (externer Link, öffnet neues Fenster)

Nucleic Acids Research, Volume 52, Issue 10, 2024


Katrin Schwank, Catharina Schmid, Tobias Fremter, Christoph Engel, Philipp Milkereit, Joachim Griesenbeck und Herbert Tschochner

Features of yeast RNA polymerase I with special consideration of the lobe binding subunits (externer Link, öffnet neues Fenster)

Biological Chemistry, DOI:10.1515/hsz-2023-0184, 2023 


Julia L. Daiß , Joachim Griesenbeck, Herbert Tschochner und Christoph Engel$

Synthesis of the ribosomal RNA precursor in human cells: mechanisms, factors and regulation (externer Link, öffnet neues Fenster)

Biological Chemistry, DOI: 10.1515/hsz-2023-0214, 2023


Yutaro Hori,  Christoph Engel$ and Takehiko Kobayashi$

Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes (externer Link, öffnet neues Fenster)

Nature Reviews Molecular Cell Biology, 24, pages: 414–429, 2023


Julia L DaißMichael Pilsl, Kristina Straub, Andrea Bleckmann, Mona HöcherlFlorian B Heiss, Guillermo Abascal-Palacios, Ewan P Ramsay, Katarina Tlučková, Jean-Clement Mars, Torben Fürtges, Astrid Bruckmann, Till Rudack, Carrie Bernecky, Valérie Lamour, Konstantin Panov, Alessandro Vannini, Tom Moss, Christoph Engel$ 

The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans (externer Link, öffnet neues Fenster) 

Life Science Alliance, DOI: 10.26508/Isa.202201568, 2022


Katherine M. Hannan, Priscilla Soo, Mei S. Wong, Justine K. Lee, …, Christoph Engel, Amee J. George

Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway (externer Link, öffnet neues Fenster)

Cell Reports, DOI:10.1016/j.celrep.2022.111571, 2022


Michael Pilsl, Herbert Tschochner, Joachim Griesenbeck & Christoph Engel$

RNA-Polymerase I: einer spezialisierten Transkriptionsmaschine auf der Spur (externer Link, öffnet neues Fenster)

BIOspektrum, Volume 28, page 484-487, 2022


Michael Pilsl, Florian B. Heiss, Gisela Pöll, Mona Höcherl, Philipp Milkereit, Christoph Engel$

Preparation of RNA Polymerase Complexes for Their Analysis by Single-Particle Cryo-Electron Microscopy (externer Link, öffnet neues Fenster)

Methods in Molecular Biology, volume 2533, 2022


Michael Pilsl, Christoph Engel $ 

Structural Studies of Eukaryotic RNA Polymerase I Using Cryo-Electron Microscopy (externer Link, öffnet neues Fenster)

Methods in Molecular Biology, volume 2533, 2022


Qianmin Wang*, Julia L. Daiß*, Youwei Xu$Christoph Engel$

Snapshots of RNA polymerase III in action – A mini review (externer Link, öffnet neues Fenster)

Gene (821), 146282, ISSN 0378-1119, 2022


Inga V. Hochheiser, Michael Pilsl, Gregor Hagelueken, Jonas Moecking, Michael Marleaux, Rebecca Brinkschulte, Eicke Latz, Christoph Engel, Matthias Geyer

Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3 (externer Link, öffnet neues Fenster)

Nature, 2022


Florian B. Heiss, Julia L. Daiß, Philipp Becker, and Christoph Engel$.                    

Conserved strategies of RNA polymerase I hibernation and activation (externer Link, öffnet neues Fenster)
Nature communications 12, 758, 2021


William J. Andrews; Swagat Ray; Tatiana Panova; Christoph Engel; Konstantin I Panov

DNA Intercalators Inhibit Eukaryotic Ribosomal RNA Synthesis by Impairing the Initiation of Transcription (externer Link, öffnet neues Fenster)
Genes 12 (9)., 2021


Cathia Rausch, Peng Zhang, Corella S Casas-Delucchi, Julia L Daiß, Christoph Engel, Gideon Coster, Florian D Hastert, Patrick Weber, M Cristina Cardoso
Cytosine base modifications regulate DNA duplex stability and metabolism (externer Link, öffnet neues Fenster)

Nucleic acids research2021


Philipp E Merkl, Michael Pilsl, Tobias Fremter, Katrin Schwank, Christoph Engel, Gernot Längst, Philipp Milkereit, Joachim Griesenbeck, Herbert Tschochner
 RNA polymerase I (Pol I) passage through nucleosomes depends on Pol I subunits binding its lobe structur (externer Link, öffnet neues Fenster)
The Journal of biological chemistry 295 (15), S. 4782–4795, 2020


Kevin Kramm, Tim Schröder, Jerome Gouge, Andrés M Vera, Kapil Gupta, Florian B Heiss, Tim Liedl, Christoph Engel, Imre Berger, Alessandro Vannini, Philip Tinnefeld, Dina Grohman
DNA origami-based single-molecule force spectroscopy elucidates RNA Polymerase III pre-initiation complex stability.  (externer Link, öffnet neues Fenster)
Nature Communications 11,  2828, 2020



Ewan P Ramsay*, Guillermo Abascal-Palacios*, Julia L Daiß*, Helen King, Jerome Gouge, Michael Pilsl, Fabienne Beuron, Edward Morris, Philip Gunkel, Christoph Engel$, Alessandro Vannini$ 
Structure of human RNA polymerase III  (externer Link, öffnet neues Fenster)
Nature communications 11, 6409, 2020


Kevin Kramm; Christoph Engel; Dina Grohmann
Transcription initiation factor TBP: old friend new questions (externer Link, öffnet neues Fenster)
Biochemical Society transactions 47 (1), S. 411–423., 2019


Christoph Engel$, Simon Neyer, and Patrick Cramer$
Distinct Mechanisms of Transcription Initiation by RNA Polymerases I and II (externer Link, öffnet neues Fenster)
Annu Rev Biophys . 47, 425-446, 2018


Christoph Engel*, Tobias Gubbey*, Simon Neyer*, Sarah Sainsbury, Christiane Oberthuer, Carlo Baejen, Carrie Bernecky, and Patrick Cramer 
Structural basis of RNA polymerase I transcription initiation (externer Link, öffnet neues Fenster) 
Cell, , 169(1), 120-131, 2017


Simon Neyer*, Michael Kunz*, Christian Geiss, Merle Hantsche, Victor-Valentin Hodirnau, Anja Seybert, Christoph Engel, Margot Scheffer, Patrick Cramer, and Achilleas S. Frangakis 
Structure of RNA polymerase I transcribing rDNA gene (externer Link, öffnet neues Fenster) 
Nature, 540 (7634), 607-610, 2016


Christoph Engel, Jürgen Plitzko, and Patrick Cramer 
RNA polymerase I-Rrn3 complex at 4.8 Å resolution (externer Link, öffnet neues Fenster)
Nature Communications, 7:12129, 2016



Ana Lisica, Christoph Engel*, Marcus Jahnel*, Eric A. Galburt*, Edgar Roldan, Patrick Cramer and Stephan W. Grill
Mechanisms of backtrack recovery by RNA polymerases I and II (externer Link, öffnet neues Fenster)
Proc Natl Acad Sci U S A, 113(11):2946-51, 2016


Dirk Kostrewa*, Claus Kuhn*, Christoph Engel and Patrick Cramer 
An alternative RNA polymerase I structure reveals a dimer hinge (externer Link, öffnet neues Fenster)
Acta Crystallogr D, 71(Pt 9):1850-5, 2015


Christoph Engel, Sarah Sainsbury, Alan C. Cheung, Dirk Kostrewa and Patrick Cramer
RNA polymerase I structure and transcription regulation (externer Link, öffnet neues Fenster) 
Nature, 502(7473):650-5., 2013


Gert Bange*, Nico Kuemmerer*, Christoph Engel, Gunes Bozkurt, Klemens Wild and Irmgard Sinning
FlhA provides the adaptor for coordinated delivery of late flagella building blocks to the type III secretion system (externer Link, öffnet neues Fenster) 
Proc Natl Acad Sci U S A, 107(25):11295-300, 2010


These authors contributed equally

$ Corresponding author

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