Publications

Sombuddha Sengupta, Rajat Mukherjee, Michael Pilsl, Siddharam Bagale, Arijit das Adhikary, Aditi N. Borkar, Pushpangadan Indira Pradeepkumar, Christoph Engel, … and Ruchi Anand

Mechanistic insights into 50S precursor recognition and targeting by erythromycin resistance methyltransferase (externer Link, öffnet neues Fenster)

Science Advances, 2025

Gunnar Mair, Julia L. Daiß, Christoph Engel^$ und Konstantin I Panov^$

The ribosomal RNA transcription landscapes of Plasmodium falciparum und related apicomplexan parasites (externer Link, öffnet neues Fenster)

Nucleic Acids Research, 2025

Daniela Tarau, Felix Grünberger, Michael Pilsl, Robert Reichelt, Florian Heiß, Sabine König, Henning Urlaub, Winfried Hausner, Christoph Engel^$ und Dina Grohmann^$

Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment (externer Link, öffnet neues Fenster)

Nucleic Acids Research, 2024

Katrin Schwank, Catharina Schmid, Tobias Fremter, Christoph Engel, Philipp Milkereit, Joachim Griesenbeck und Herbert Tschochner

Features of yeast RNA polymerase I with special consideration of the lobe binding subunits (externer Link, öffnet neues Fenster)

Biological Chemistry, 2023 

Julia L. Daiß , Joachim Griesenbeck, Herbert Tschochner und Christoph Engel^$

Synthesis of the ribosomal RNA precursor in human cells: mechanisms, factors and regulation (externer Link, öffnet neues Fenster)

Biological Chemistry, 2023

Yutaro Hori,  Christoph Engel^$ and Takehiko Kobayashi^$

Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes (externer Link, öffnet neues Fenster)

Nature Reviews Molecular Cell Biology, 2023

Julia L Daiß, Michael Pilsl, Kristina Straub, Andrea Bleckmann, Mona Höcherl, Florian B Heiss, Guillermo Abascal-Palacios, Ewan P Ramsay, Katarina Tlučková, Jean-Clement Mars, Torben Fürtges, Astrid Bruckmann, Till Rudack, Carrie Bernecky, Valérie Lamour, Konstantin Panov, Alessandro Vannini, Tom Moss, Christoph Engel^$ 

The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans (externer Link, öffnet neues Fenster) 

Life Science Alliance, 2022

Katherine M. Hannan, Priscilla Soo, Mei S. Wong, Justine K. Lee, …, Christoph Engel, Amee J. George

Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway (externer Link, öffnet neues Fenster)

Cell Reports, 2022

Michael Pilsl, Herbert Tschochner, Joachim Griesenbeck & Christoph Engel^$

RNA-Polymerase I: einer spezialisierten Transkriptionsmaschine auf der Spur (externer Link, öffnet neues Fenster)

BIOspektrum, 2022

Michael Pilsl, Florian B. Heiss, Gisela Pöll, Mona Höcherl, Philipp Milkereit, Christoph Engel^$

Preparation of RNA Polymerase Complexes for Their Analysis by Single-Particle Cryo-Electron Microscopy (externer Link, öffnet neues Fenster)

Methods in Molecular Biology, 2022

Michael Pilsl, Christoph Engel ^$ 

Structural Studies of Eukaryotic RNA Polymerase I Using Cryo-Electron Microscopy (externer Link, öffnet neues Fenster)

Methods in Molecular Biology, 2022

Qianmin Wang*, Julia L. Daiß*, Youwei Xu^$, Christoph Engel^$

Snapshots of RNA polymerase III in action – A mini review (externer Link, öffnet neues Fenster)

Gene (821), 2022

Inga V. Hochheiser, Michael Pilsl, Gregor Hagelueken, Jonas Moecking, Michael Marleaux, Rebecca Brinkschulte, Eicke Latz, Christoph Engel, Matthias Geyer

Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3 (externer Link, öffnet neues Fenster)

Nature, 2022

Florian B. Heiss, Julia L. Daiß, Philipp Becker, and Christoph Engel^$.                    

Conserved strategies of RNA polymerase I hibernation and activation (externer Link, öffnet neues Fenster)

Nature communications, 2021

William J. Andrews; Swagat Ray; Tatiana Panova; Christoph Engel; Konstantin I Panov

DNA Intercalators Inhibit Eukaryotic Ribosomal RNA Synthesis by Impairing the Initiation of Transcription (externer Link, öffnet neues Fenster)

Genes 12 (9)., 2021

Cathia Rausch, Peng Zhang, Corella S Casas-Delucchi, Julia L Daiß, Christoph Engel, Gideon Coster, Florian D Hastert, Patrick Weber, M Cristina Cardoso

Cytosine base modifications regulate DNA duplex stability and metabolism (externer Link, öffnet neues Fenster)

Nucleic acids research, 2021

Philipp E Merkl, Michael Pilsl, Tobias Fremter, Katrin Schwank, Christoph Engel, Gernot Längst, Philipp Milkereit, Joachim Griesenbeck, Herbert Tschochner

RNA polymerase I (Pol I) passage through nucleosomes depends on Pol I subunits binding its lobe structur (externer Link, öffnet neues Fenster)

The Journal of biological chemistry 295, 2020

Kevin Kramm, Tim Schröder, Jerome Gouge, Andrés M Vera, Kapil Gupta, Florian B Heiss, Tim Liedl, Christoph Engel, Imre Berger, Alessandro Vannini, Philip Tinnefeld, Dina Grohman

DNA origami-based single-molecule force spectroscopy elucidates RNA Polymerase III pre-initiation complex stability.  (externer Link, öffnet neues Fenster)

Nature Communications 11, 2020

Michael Pilsl, and Christoph Engel^$ 

Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting  (externer Link, öffnet neues Fenster)

Nature Communications 11, 2020

Ewan P Ramsay*, Guillermo Abascal-Palacios*, Julia L Daiß*, Helen King, Jerome Gouge, Michael Pilsl, Fabienne Beuron, Edward Morris, Philip Gunkel, Christoph Engel^$, Alessandro Vannini^$ 

Structure of human RNA polymerase III  (externer Link, öffnet neues Fenster)

Nature communications 11, 2020

Kevin Kramm; Christoph Engel; Dina Grohmann

Transcription initiation factor TBP: old friend new questions (externer Link, öffnet neues Fenster)

Biochemical Society transactions 47, 2019

Christoph Engel^$, Simon Neyer, and Patrick Cramer^$

Distinct Mechanisms of Transcription Initiation by RNA Polymerases I and II (externer Link, öffnet neues Fenster)

Annu Rev Biophys, 2018

Christoph Engel*, Tobias Gubbey*, Simon Neyer*, Sarah Sainsbury, Christiane Oberthuer, Carlo Baejen, Carrie Bernecky, and Patrick Cramer 

Structural basis of RNA polymerase I transcription initiation (externer Link, öffnet neues Fenster) 

Cell, 2017

Simon Neyer*, Michael Kunz*, Christian Geiss, Merle Hantsche, Victor-Valentin Hodirnau, Anja Seybert, Christoph Engel, Margot Scheffer, Patrick Cramer, and Achilleas S. Frangakis 

Structure of RNA polymerase I transcribing rDNA gene (externer Link, öffnet neues Fenster) 

Nature, 2016

Christoph Engel, Jürgen Plitzko, and Patrick Cramer 

RNA polymerase I-Rrn3 complex at 4.8 Å resolution (externer Link, öffnet neues Fenster)

Nature Communications, 2016

Christoph Engel^$

Purification of crystallization-grade RNA polymerase I from S. cerevisiae (externer Link, öffnet neues Fenster)

Methods Mol Biol, 2016

Ana Lisica, Christoph Engel*, Marcus Jahnel*, Eric A. Galburt*, Edgar Roldan, Patrick Cramer and Stephan W. Grill

Mechanisms of backtrack recovery by RNA polymerases I and II (externer Link, öffnet neues Fenster)

Proc Natl Acad Sci U S A, 2016

Dirk Kostrewa*, Claus Kuhn*, Christoph Engel and Patrick Cramer 

An alternative RNA polymerase I structure reveals a dimer hinge (externer Link, öffnet neues Fenster)

Acta Crystallogr D, 2015

Christoph Engel, Sarah Sainsbury, Alan C. Cheung, Dirk Kostrewa and Patrick Cramer

RNA polymerase I structure and transcription regulation (externer Link, öffnet neues Fenster) 

Nature, 2013

Gert Bange*, Nico Kuemmerer*, Christoph Engel, Gunes Bozkurt, Klemens Wild and Irmgard Sinning

FlhA provides the adaptor for coordinated delivery of late flagella building blocks to the type III secretion system (externer Link, öffnet neues Fenster)

Proc Natl Acad Sci U S A, 2010