Publikationen

Helmbrecht V, Reichelt R, Grohmann D, Orsi WD. Simulated early Earth geochemistry fuels a hydrogen-dependent primordial metabolism.
Nat Ecol Evol. 2025 May;9(5):769-778. doi: 10.1038/s41559-025-02676-w (externer Link, öffnet neues Fenster). Epub 2025 Apr 30.

Grohmann D, Grünberger F. Single-molecule sequencing of RNA.
American Chemical Society. 2025 April 24; doi: 10.1021/acsinfocus.7e9002 (externer Link, öffnet neues Fenster)

Hanelt TN, Treiber N, Treiber T, Lehmann G, Eichner N, Rothmeier T, Schmid G, Reichelt R, Zambelli F, Pavesi G, Grohmann D, Meister G. Endo-bind-n-seq: identifying RNA motifs of RNA binding proteins isolated from endogenous sources.
Life Sci Alliance. 2024 Dec 2;8(2):e202402782. doi: 10.26508/lsa.202402782 (externer Link, öffnet neues Fenster)

Tarau D, Grünberger F, Pilsl M, Reichelt R, Heiß F, König S, Urlaub H, Hausner W, Engel C, Grohmann D. Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment.
Nucleic Acids Research, gkae282, https://doi.org/10.1093/nar/gkae282 (externer Link, öffnet neues Fenster)

Vornholt T, Joncev Z,  Sabatino V,  Panke S,  Ward T.R,  Sparr C,  Jeschek M. An artificial metalloenzyme for atroposelective metathesis. ChemCatChem e202301113. doi:10.1002/cctc.202301113 (externer Link, öffnet neues Fenster)

Grünberger F, Schmid G, El Ahmad Z, Fenk M, Vogl K, Reichelt R, Hausner W,
Urlaub H, Lenz C, Grohmann D. Uncovering the temporal dynamics and regulatory
networks of thermal stress response in a hyperthermophile using transcriptomics
and proteomics. mBio. 2023 Oct 16:e0217423. doi: 10.1128/mbio.02174-23 (externer Link, öffnet neues Fenster)

Kramm K, Schröder T, Vera AM, Grabenhorst L, Tinnefeld P, Grohmann D. DNA Origami-Based Single-Molecule Force Spectroscopy and Applications. Methods Mol Biol. 2024;2694:479-507. doi: 10.1007/978-1-0716-3377-9_23 (externer Link, öffnet neues Fenster)

Reichelt R, Rothmeier T, Grünberger F, Willkomm S, Bruckmann A, Hausner W, Grohmann D. The archaeal Lsm protein from Pyrococcus furiosus binds co- transcriptionally to poly(U)-rich target RNAs. Biol Chem. 2023 Sep 15.
doi: 10.1515/hsz-2023-0215 (externer Link, öffnet neues Fenster)

Baes R, Grünberger F, Pyr Dit Ruys S, Couturier M, De Keulenaer S, Skevin S, Van Nieuwerburgh F, Vertommen D, Grohmann D, Ferreira-Cerca S, Peeters E. Transcriptional and translational dynamics underlying heat shock response in the thermophilic crenarchaeon Sulfolobus acidocaldarius. mBio. 2023 Aug 29:e0359322.
doi: 10.1128/mbio.03593-22 (externer Link, öffnet neues Fenster)

Agam G, Gebhardt C, Popara M, Mächtel R, Folz J, Ambrose B, Chamachi N, Chung SY, Craggs TD, de Boer M, Grohmann D, Ha T, Hartmann A, Hendrix J, Hirschfeld V, Hübner CG, Hugel T, Kammerer D, Kang HS, Kapanidis AN, Krainer G, Kramm K, Lemke EA, Lerner E, Margeat E, Martens K, Michaelis J, Mitra J, Moya Muñoz GG, Quast RB, Robb NC, Sattler M, Schlierf M, Schneider J, Schröder T, Sefer A, Tan PS, Thurn J, Tinnefeld P, van Noort J, Weiss S, Wendler N, Zijlstra N, Barth A, Seidel CAM, Lamb DC, Cordes T. Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins. Nat Methods. 2023 Apr;20(4):523-535.
doi: 10.1038/s41592-023-01807-0 (externer Link, öffnet neues Fenster)

Seeholzer T, Tarau D, Hollendonner L, Auer A, Rachel R, Grohmann D, Giessibl FJ, Weymouth AJ. A Next-Generation qPlus-Sensor-Based AFM Setup: Resolving Archaeal S-Layer Protein Structures in Air and Liquid. J Phys Chem B. 2023 Aug 10;127(31):6949-6957. doi: 10.1021/acs.jpcb.3c02875 (externer Link, öffnet neues Fenster)

Dengler L, Meier J, Klingl A, Nißl L, Bellack A, Grohmann D, Rachel R, Huber H. A novel interdomain consortium from a Costa Rican oil well composed of Methanobacterium cahuitense sp. nov. and Desulfomicrobium aggregans sp. nov. 
Arch Microbiol. 2023 Apr 13;205(5):189. doi: 10.1007/s00203-023-03533-9 (externer Link, öffnet neues Fenster).

Grünberger F, Jüttner M, Knüppel R, Ferreira-Cerca S*, Grohmann D.* Nanopore-based RNA sequencing deciphers the formation, processing, and modification steps of rRNA intermediates in archaea. RNA. 2023 Aug;29(8):1255-1273. 
doi:10.1261/rna.079636.123 (externer Link, öffnet neues Fenster)

S. Höllerer, M. Jeschek. Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet base pairing of initiator tRNA and transcript. 
Nucleic Acids Research gkad040, https://doi.org/10.1093/nar/gkad040 (externer Link, öffnet neues Fenster)

Kaul A., Böllmann A., Thema M., Kalb L., Stöckl R., Huber H., Sterner M., Bellack A. (2022). Combining a robust thermophilic methanogen and packing material with high liquid hold-up to optimize biological methanation in trickle-bed reactors. 
Bioresource Technology 345:126524. doi: 10.1016/j.biortech.2021.126524 (externer Link, öffnet neues Fenster)

Dengler L, Meier J, Grünberger F, Bellack A, Rachel R, Grohmann D, Huber H. Methanofollis propanolicus sp. nov., a novel archaeal isolate from a Costa Rican oil well that uses propanol for methane production. Arch Microbiol. 2022 Aug 13;204(9):554.
doi: 10.1007/s00203-022-03152-w (externer Link, öffnet neues Fenster)

Gambelli L., Isupov M. N., Conners R., McLaren M., Bellack A., Gold V., Rachel R., Daum B. (2022). An archaellum filament composed of two alternating subunits. 
Nature Communications 13:710. doi: 10.1038/s41467-022-28337-1 (externer Link, öffnet neues Fenster)

Willkomm S., Jakob L., Kramm K., Graus V., Neumeier J., Meister G., Grohmann D. (2022). Single-molecule FRET uncovers hidden conformations and dynamics of human Argonaute 2. 
Nat Commun 13, 3825. https://doi.org/10.1038/s41467-022-31480-4 (externer Link, öffnet neues Fenster)

Buriánková, I.; Molíková, A.; Vítězová, M.; Onderka, V.; Vítěz, T.; Urbanová, I.; Hanišáková, N.; Černý, M.; Novák, D.; Lochman, J.; Zeman, J.; Javůrek, J.; Machálková, M.; Dengler, L.; Huber, H. (2022). Microbial Communities in Underground Gas Reservoirs Offer Promising Biotechnological Potential. 
Fermentation 2022, 8, 251. https://doi.org/10.3390/fermentation8060251  (externer Link, öffnet neues Fenster)

S. Höllerer, M. Jeschek. (2022). Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet base pairing of initiator tRNA and transcript. 
bioRxiv doi: https://doi.org/10.1101/2022.05.02.490318 (externer Link, öffnet neues Fenster)

Wörle E, Newman A, D'Silva J, Burgio G, Grohmann D. Allosteric activation of CRISPR-Cas12a requires the concerted movement of the bridge helix and helix 1 of the RuvC II domain. 
Nucleic Acids Res. 2022 Sep 23;50(17):10153-10168. doi:10.1093/nar/gkac767 (externer Link, öffnet neues Fenster)

Grünberger F., Ferreira-Cerca S. and Grohmann D. (2022) Nanopore sequencing of RNA and cDna molecules in Escherichia coli. RNA 28(3): 400-417.
doi: 10.1261/rna.078937.121 (externer Link, öffnet neues Fenster)

Thema M., Weidlich T., Kaul A., Böllmann A., Huber H., Bellack A., Karl J., Sterner M. (2021). Optimized biological CO2-methanation with a pure culture of thermophilic methanogenic archaea in a trickle-bed reactor. 
Bioresource Technology 333:125135. doi: 10.1016/j.biortech.2021.125135 (externer Link, öffnet neues Fenster)

T. Vornholt, F. Christoffel, M. Pellizzoni, S. Panke, T.R. Ward, M. Jeschek. (2021). Systematic engineering of artificial metalloenzymes for new-to-nature reactions. 
Science Advances 7:eabe4208, https://www.science.org/doi/pdf/10.1126/sciadv.abe4208 (externer Link, öffnet neues Fenster)

Wörle E., Jakob L., Schmidbauer A., Zinner G., Grohmann D. (2021). Decoupling the bridge helix of Cas12a results in a reduced trimming activity, increased mismatch sensitivity and impaired conformational transitions. 
Nucleic Acids Research, https://doi.org/10.1093/nar/gkab286 (externer Link, öffnet neues Fenster)

Weixlbaumer A., Grünberger F., Werner F. and Grohmann D. (2021). Coupling of transcription and translation in archaea: cues from the bacterial world. 
Frontiers in Microbiology.  https://doi.org/10.3389/fmicb.2021.661827 (externer Link, öffnet neues Fenster)

Grünberger F., Reichelt R., Waege I., Niedermaier V., Bronner K., Kaljanac M., Weber N., El Ahmad Z., Madej G., Knauss L., Ziegler C., Grohmann D., Hausner W. (2021) CopR, a global regulator of transcription to maintain copper homeostasis in Pyrococcus furiosus. Frontiers in Microbiology. doi:10.3389 (externer Link, öffnet neues Fenster)

T. Vornholt, M. Jeschek. (2020) The quest for xenobiotic enzymes ‐ from new enzymes for chemistry to a novel chemistry of life. 
ChemBioChem, 21:2241-2249. https://www.science.org/doi/10.1126/sciadv.abe4208 (externer Link, öffnet neues Fenster)

S. Höllerer, L. Papaxanthos, A.C. Gumpinger, K. Fischer, C. Beisel, K. Borgwardt, Y. Benenson, M. Jeschek. (2020) Large-scale DNA-based phenotypic recording and deep learning enable highly accurate sequence-function mapping. 
Nature Communications 11:3551. https://www.nature.com/articles/s41467-020-17222-4 (externer Link, öffnet neues Fenster)

Buckley R.J., Kramm K., Cooper C.D.O., Grohmann D., Bolt E. L. (2020) Mechanistic insights into Lhr helicase function in DNA repair. Biochemical Journal. 477 (16): 2935–2947. DOI:10.1042/BCJ20200379 (externer Link, öffnet neues Fenster).

Kramm K., Schröder T., Gouge J., Vera A. M., Gupta K., Heiss F.B., Liedl T., Engel C., Berger I., Vannini A., Tinnefeld P. and Grohmann D. (2020). DNA origami-based single-molecule force spectroscopy elucidates RNA Polymerase III pre-initiation complex stability. 
Nature Communications 11: 2828. doi: 10.1038/s41467-020-16702-x. (externer Link, öffnet neues Fenster)

Liu L., Huber H., Berg I. A. (2020). Enzymes catalyzing crotonyl-CoA conversion to acetoacetyl-CoA during the autotrophic CO2 fixation in Metallosphaera sedula.
Front. Microbiol. 11; doi:10.3389/fmicb.2020.00354. (externer Link, öffnet neues Fenster)

Eder W., Tindall B. J., Huber H., Peplies J., Wirth R. (2020). Recognition of the unsuitability of DSM 12173 as the deposited type strain of Thermocrinis ruber Huber et al. 1999, recognition of DSM 23557 as an authentic sub‑culture of strain OC 1/4, the nomenclatural type of Thermocrinis ruber Huber et al. 1999 and an emended description of Thermocrinis ruber Huber et al. 1999. 
Archives of Microbiology. doi: 10.1007/s00203-020-01850-x. (externer Link, öffnet neues Fenster)

Eckl D. B., Huber H., Bäumler W. (2020). First report on Photodynamic Inactivation of Archaea including a novel method for high-throughput reduction measurement. 
Photochemistry and Photobiology. doi: 10.1111/php.13229 (externer Link, öffnet neues Fenster).

Rose S., Auxilien S., Havelund J. F., Kirpekar F., Huber H., Grosjean H., Douthwaite S. (2020). The hyperthermophilic partners Nanoarchaeum and Ignicoccus stabilize their tRNA T-loops via different but structurally equivalent modifications. 
Nucleic acids research. doi: 10.1093/nar/gkaa411 (externer Link, öffnet neues Fenster).

S. Wu, Y. Zhou, D. Gerngross, M. Jeschek, T.R. Ward. (2019) Chemo-enzymatic cascades to produce cycloalkenes from bio-based resources. 
Nature Communications 10:5060. https://www.nature.com/articles/s41467-019-13071-y (externer Link, öffnet neues Fenster)

Kramm K., Endesfelder U., Grohmann D. (2019). A single-molecule view of archaeal transcription. 
Journal of Molecular Biology. doi: 10.1016/j.jmb.2019.06.009 (externer Link, öffnet neues Fenster).

Grünberger F., Reichelt R.M., Bunk B., Spröer C., Overmann J., Rachel R., Grohmann D., Hausner W. (2019) Next generation DNA-Seq and differential RNA-Seq allow re-annotation of the Pyrococcus furiosus DSM 3638 genome and provide insights into archaeal antisense transcription. 
Frontiers in Microbiology 10, 1603. doi: 10.3389/fmicb.2019.01603. (externer Link, öffnet neues Fenster)

Kramm K., Engel C., Grohmann D. (2019) Transcription factor TBP: Old friend new questions. 
Biochem Soc Trans. 47: 411 – 423. doi: 10.1042/BST20180623 (externer Link, öffnet neues Fenster).

Jakob L., Gust A., Grohmann D. (2019) Evaluation and optimisation of unnatural amino acid incorporation and bioorthogonal bioconjugation for site-specific fluorescent labelling of proteins expressed in mammalian cells. 
Biochemistry and Biophysics Reports 17, 1-9. doi: 10.1016/j.bbrep.2018.10.011 (externer Link, öffnet neues Fenster).

Kreuter L. J., Weinfurtner A., Ziegler A., Weigl J., Hoffmann J., Morgner N. , Müller V., Huber H. (2019). Purification of a crenarchaeal ATP synthase in the light of the unique bioenergetics of Ignicoccus species. 
J. Bacteriol. Vol 201, e00510-18; doi: 10.1128/JB.00510-18 (externer Link, öffnet neues Fenster).

Thema M., Weidlich T., Hörl M., Bellack A., Mörs F., Hackl F., Kohlmayer M., Gleich J., Stabenau C., Trabold T., Neubert M., Ortlo F., Brotsack R., Schmack D., Huber H.,  Hafenbradl D., Karl J., Sterner M. (2019). 
Biological CO2-Methanation: An Approach to Standardization. Energies 12, 1670; doi: 10.3390/en12091670 (externer Link, öffnet neues Fenster).

T. Heinisch, F. Schwizer, B. Garabedian, E. Csibra, M. Jeschek, J. Vallapurackal, V.B. Pinheiro, P. Marlière, S. Panke, T.R. Ward. (2018). E. coli surface display of streptavidin for directed evolution of an allylic deallylase. 
Chemical Science 9:5383–5388. https://pubs.rsc.org/en/content/articlelanding/2018/sc/c8sc00484f (externer Link, öffnet neues Fenster)

M. Jeschek, S. Panke, T.R. Ward. (2018) Artificial metalloenzymes on the verge of new-to-nature metabolism. 
Trends in Biotechnology 36:60-72. https://pubs.rsc.org/en/content/articlelanding/2018/sc/c8sc00484f (externer Link, öffnet neues Fenster)

Reichelt R., Grohmann D., Willkomm S. (2018) A journey through the evolutionary diversification of archaeal Lsm and Hfq proteins. 
Emerging topics in life sciences. 2: 647-657. doi: 10.1042/ETLS20180034 (externer Link, öffnet neues Fenster).

Dexl S., Reichelt R., Kraatz K., Schulz S., Grohmann D., Bartlett M., Thomm M. (2018) Displacement of the Transcription Factor B Reader Domain during Transcription Initiation. 
Nucleic Acids Research. 46: 10066 – 10081. doi: 10.1093/nar/gky699. (externer Link, öffnet neues Fenster)

Molle J., Jakob L., Bohlen J., Raab M., Tinnefeld P., Grohmann D. (2018) Towards Structural Biology with Super-Resolution Microscopy. 
Nanoscale. 10: 16416 – 16424. doi: 10.1039/c8nr03361g (externer Link, öffnet neues Fenster).

Willkomm S., Makaraova K. and Grohmann D., (2018) Prokaryotic Argonaute proteins represent an additional layer in prokaryotic defence.
FEMS Microbiology Reviews. 42:376-387. doi: 10.1093/femsre/fuy010. (externer Link, öffnet neues Fenster)

Gust A., Jakob L., Zeitler D., Willkomm S., Kramm K., Tinnefeld P., Meister G. and Grohmann D. (2018) Site-specific fluorescent labelling of endogenous mammalian proteins for single-molecule FRET analysis. 
ChemBioChem. 19:780-783. doi: 10.1002/cbic.201700696 (externer Link, öffnet neues Fenster).

M. Jeschek, M.O. Bahls, V. Schneider, P. Marlière, T.R. Ward, S. Panke. (2017). Biotin-independent strains of Escherichia coli for enhanced streptavidin production. 
Metabolic Engineering 40:33-40. https://pubmed.ncbi.nlm.nih.gov/28062280/ (externer Link, öffnet neues Fenster)

Blombach F. and Grohmann D. (2017). Same same but different: the evolution of TBP in archaea and their eukaryotic offspring. 
Transcription. 8:162-168. doi: 10.1080/21541264.2017.1289879. (externer Link, öffnet neues Fenster)

M. Jeschek, D. Gerngross, S. Panke. (2017) Combinatorial pathway optimization for streamlined metabolic engineering. 
Current Opinion in Biotechnology 47:142-151. https://pubmed.ncbi.nlm.nih.gov/28750202/ (externer Link, öffnet neues Fenster)

Gouge J., Guthertz N., Dergai O., Kramm K., Abascal-Palacios G., Satia K., Cousin P., Nouria Hernandez N., Grohmann D. and Vannini A. (2017). Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA Polymerase III transcription initiation. 
Nature Structural and Molecular Biology, Nature Communications. 8(1): 130. doi: 10.1038/s41467-017-00126-1. (externer Link, öffnet neues Fenster)

Willkomm S., Zander A. and Grohmann D. (2017). Site-Specific Fluorescent Labeling of Argonaute for FRET-based Bio-Assays. 
Methods in Molecular Biology, 1517:291-304. doi: 10.1007/978-1-4939-6563-2_20 (externer Link, öffnet neues Fenster).

Zander A., Willkomm S., Ofer S., van Wolferen M., Egert L., Buchmeier S., Stöckl S., Tinnefeld P., Schneider S., Klingl A., Albers S.-V., Werner F. and Grohmann D. (2016). Guide-independent DNA silencing by archaeal Argonaute. 
Nature Microbiology. 2: 17034. doi: 10.1038/nmicrobiol.2017.35. (externer Link, öffnet neues Fenster)

Willkomm S, Oellig C. A., Zander A., Restle T., Keegan R., Grohmann D.* and Schneider, S. (2016). Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein. 
Nature Microbiology. 2:17035. doi: 10.1038/nmicrobiol.2017.35. (externer Link, öffnet neues Fenster)

Kucher S, Korneev S. Tyagi S., Apfelbaum R., Grohmann D., Lemke E.A., Klare, J., Steinhoff H.-J., Klose, D. (2016) Orthogonal spin labelling using click chemistry for in vitro and in vivo applications. 
Journal of Magnetic Resonance, 275:38-45. doi: 10.1016/j.jmr.2016.12.001 (externer Link, öffnet neues Fenster).

M. Jeschek, S. Panke, T. R. Ward. (2016). Periplasmic screening for artificial metalloenzymes. 
Methods in Enzymology 580:539-556. https://pubmed.ncbi.nlm.nih.gov/27586348/ (externer Link, öffnet neues Fenster)

M. Jeschek, R. Reuter, T. Heinisch, C. Trindler, J. Klehr, S. Panke, T.R. Ward. (2016). Directed evolution of artificial metalloenzymes for in vivo metathesis. 
Nature 537:661-665. https://www.nature.com/articles/nature19114 (externer Link, öffnet neues Fenster)

M. Jeschek, D. Gerngross, S. Panke. (2016) Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort. 
Nature Communications 7:11163. https://www.nature.com/articles/ncomms11163 (externer Link, öffnet neues Fenster)

Sheppard C., Blombach F., Belsom A., Schulz S., Daviter T., Smollett K., Mahieu E., Erdmann S., Tinnefeld P., Garrett R., Grohmann D., Rappsilber J., Werner F. (2016) Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP. 
Nature Communications, 7:13595. doi: 10.1038/ncomms13595 (externer Link, öffnet neues Fenster).

Nickels P.C., Wünsch B., Holzmeister P., Bae W., Kneer L.M., Grohmann D., Tinnefeld P. and Liedl T. (2016), Molecular Force Spectroscopy with a DNA Origami-Based Nanoscopic Force Clamp. 
Science. 354(6310):305-307. doi: 10.1126/science.aah5974 (externer Link, öffnet neues Fenster).

Willkomm S., Zander A., Grohmann D. and Restle T. (2016). Mechanistic insights into archaeal and human Argonaute substrate binding and cleavage properties. 
PLOS one, 11(10):e0164695. doi: 10.1371/journal.pone.0164695 (externer Link, öffnet neues Fenster).

Blombach B., Smollett K.L., Grohmann D. and Werner F. (2016). Molecular Mechanisms of Transcription Initiation – structure, function and evolution of TFE/TFIIE-like factors and open complex formation. 
Journal of Molecular Biology (epub, ahead of print). doi: 10.1016/j.jmb.2016.04.016 (externer Link, öffnet neues Fenster).

Schulz S., Gietl A., Smollett K., Tinnefeld P., Werner F. and Grohmann D. (2016). TFE and Spt4/5 open and close the RNA polymerase clamp during the transcription cycle. 
PNAS (epub, ahead of print) Selected by the Faculty 1000

Jakob L., Treiber T., Treiber N., Gust A., Kramm K., Hansen K., Stotz M., Wankerl L., Herzog F., Hannus S., Grohmann D., and Meister G. (2016). Structural and functional insights into the fly microRNA biogenesis factor Loquacious. 
RNA. (epub ahead of print). doi: 10.1261/rna.055426.115 (externer Link, öffnet neues Fenster).

Molle J., Raab M., Holzmeister S., Schmitt-Monreal D., Grohmann D., He Z., Tinnefeld P. (2016). Superresolution microscopy with transient binding. 
Current Opinion in Biotechnology, 39: 8-16. doi: 10.1016/j.copbio.2015.12.009. (externer Link, öffnet neues Fenster)

Schulz S., Kramm K., Werner F., Grohmann D. (2015). A fluorescently labeled recombinant RNAP system to probe archaeal transcription initiation. 
Methods (epub, ehead of print). doi: 10.1016/j.ymeth.2015.04.017 (externer Link, öffnet neues Fenster).

Willkomm S., Zander A., Gust A., Grohmann D. (2015). A prokaryotic twist on Argonaute action. 
Life. 5 (1), 538-553. doi: 10.3390/life5010538 (externer Link, öffnet neues Fenster).

Nagy J., Grohmann D., Cheung A.C.M., Schulz S., Smollett K., Werner F. & Michaelis J. (2015): Complete architecture of the archaeal RNA polymerase open complex from single-molecule FRET and NPS. 
Nature Communications, 6:6161. doi: 10.1038/ncomms7161 (externer Link, öffnet neues Fenster)

A. Gust, A. Zander, A. Gietl, P. Holzmeister, S. Schulz, B. Lalkens, P. Tinnefeld, D. Grohmann (2014): A Starting Point for Fluorescence-Based Single-Molecule Measurements in Biomolecular Research. 
Molecules, 19, 10, 15824-15865. doi: 10.3390/molecules191015824 (externer Link, öffnet neues Fenster).

Acuna G., Grohmann D., Tinnefeld P. (2014) Enhancing single-molecule fluorescence with nanophotonics. 
FEBS letters. doi: 10.1016/j.febslet.2014.06.016 (externer Link, öffnet neues Fenster)

Gietl A., Holzmeister P., Blombach F., Schulz S., Voithenberg L.V.v., Lamb D., Werner F., Tinnefeld P., Grohmann D. (2014) Eukaryotic and Archaeal TBP and TFB/TF(II)B Follow Different Promoter DNA Bending Pathways. 
Nucleic Acids Research. 42(10):6219-31. Selected by the Faculty 1000. doi: 10.1093/nar/gku273 (externer Link, öffnet neues Fenster).

Zander A., Holzmeister P., Klose D., Tinnefeld P. and Grohmann D. (2014). Single-molecule FRET supports the two-state model of Argonaute action. 
RNA Biology 11(1):45-56. (featured image from our article). doi: 10.4161/rna.27446 (externer Link, öffnet neues Fenster).

Holzmeister P., Acuna G.P., Grohmann D. and Tinnefeld P. (2014) Breaking the Concentration Limit of Optical Single-Molecule Detection. 
Chemical Society Reviews 43(4):1014-28. (back cover). doi: 10.1039/C3CS60207A (externer Link, öffnet neues Fenster).

Afanasyeva A., Hirtreiter A., Schreiber A., Grohmann D., Pobegalov E., McKay A.R., Tsaneva I., Petukhov M., Käs E., Grigoriev M. and Werner F. (2014). Lytic water dynamics reveal evolutionarily conserved mechanisms of ATP hydrolysis by TIP49 AAA+ ATPases. 
Structure. 22(4):549-59. doi: 10.1016/j.str.2014.02.002 (externer Link, öffnet neues Fenster).

Grohmann D.*, Werner F. and Tinnefeld P. (2013). Making Connections – Strategies for Single Molecule Fluorescence Biophysics. 
Current Opinion in Chemical Biology. 17(4):691-8. doi: 10.1016/j.cbpa.2013.05.020 (externer Link, öffnet neues Fenster).

Gietl A. and Grohmann D. (2012). Modern biophysical approaches probe transcription factor induced DNA bending and looping. 
Biochem Soc Trans. 41(1):368-73. doi: 10.1042/BST20120301 (externer Link, öffnet neues Fenster).

Blombach F., Daviter T., Fielden D., Grohmann D., Smollett K. and Werner F. (2012). Archaeology of RNA polymerase – factor swapping during the transcription cycle. 
Biochem Soc Trans. 41(1):362-7. doi: 10.1038/nmicrobiol.2017.21. (externer Link, öffnet neues Fenster)

Klose D., Klare J., Grohmann D., Kay C.W.M., Werner F. and Steinhoff H-J. (2012). Simulation vs. reality: a comparison of in silico predictions with DEER and FRET measurements. 
PLOS one, 7(6):e39492. doi: 10.1371/journal.pone.0039492 (externer Link, öffnet neues Fenster).

Gietl A., Holzmeister P., Grohmann D.* and Tinnefeld P. (2012). DNA origami as biocompatible surface to match single-molecule and ensemble experiments. 
Nucleic Acids Research, epub. doi: 10.1093/nar/gks326 (externer Link, öffnet neues Fenster).

Grohmann D., Nagy J., Chakraborty A., Klose D., Fielden D., Ebright R.H., Michaelis J., Werner F. (2011). The Initiation Factor TFE and the Elongation Factor Spt4/5 Compete for the RNAP Clamp during Transcription Initiation and Elongation. 
Molecular Cell, 43:263-74. doi: 10.1016/j.molcel.2011.05.030 (externer Link, öffnet neues Fenster).

Grohmann D. and Werner F. (2011) Recent advances in the understanding of archaeal transcription. 
Curr Opin Microbiol. doi: 10.1016/j.mib.2011.04.012 (externer Link, öffnet neues Fenster).

Ryan C.P., Smith M.E., Schumacher F.F., Grohmann D., Papaioannou D., Waksman G., Werner F., Baker J.R., Caddick S. (2011) Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis. 
Chem Commun. 47:5452-4. doi: 10.1039/c1cc11114k (externer Link, öffnet neues Fenster).

Grohmann D., Klose D., Fielden D., Werner F. (2011) FRET (fluorescence resonance energy transfer) sheds light on transcription. 
Biochem Soc Trans. 39:122-7. doi: 10.1042/BST0390122 (externer Link, öffnet neues Fenster).

Werner F. and Grohmann D. (2011) Evolution of multisubunit RNA polymerases in the three domains of life. 
Nature Reviews Microbiol.9:85-98. doi: 10.1038/nrmicro2507. (externer Link, öffnet neues Fenster)

Grohmann D. and Werner F. (2011) Cycling through Transcription with the RNA polymerase F/E (RPB4/7) Complex - Structure, Function and Evolution of Archaeal RNA polymerase. 
Research in Microbiology 162:10-8. doi: 10.1016/j.resmic.2010.09.002. (externer Link, öffnet neues Fenster)

Grohmann D., Klose D., Klare J.P., Kay C.W., Steinhoff H.J., Werner F. (2010) RNA-binding to archaeal RNA polymerase subunits F/E: a DEER and FRET study. 
J Am Chem Soc., 132:5954-5. doi: 10.1021/ja101663d (externer Link, öffnet neues Fenster).

Hirtreiter A., Damsma G.E., Cheung A.C., Klose D., Grohmann D., Vojnic E., Martin A.C., Cramer P., Werner F. (2010). Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif. 
Nucleic Acids Research 38:4040-51. doi: 10.1093/nar/gkq135. (externer Link, öffnet neues Fenster)

Hirtreiter A., Grohmann D., Werner F. (2010) Molecular mechanisms of RNA polymerase – the F/E (Rpb4/7) complex is required for high processivity in vitro. 
Nucleic Acids Research, 38:585-96. doi: 10.1093/nar/gkp928. (externer Link, öffnet neues Fenster)

Grohmann, D. & Werner, F. (2010) Hold on!: RNA polymerase interactions with the nascent RNA modulate transcription elongation and termination. 
RNA Biology, 7: 310-315. doi: 10.4161/rna.7.3.11912. (externer Link, öffnet neues Fenster)

Grohmann D., Hirtreiter A., Werner F. (2009). RNAP subunits F/E (Rpb4/7) are stably associated with archaeal RNA polymerase: using fluorescence anisotropy to monitor RNAP assembly in vitro. 
Biochem J, 421:339-43. (selected by the Faculty 1000). doi: 10.1042/BJ20090782 (externer Link, öffnet neues Fenster).

Grohmann D., Hirtreiter A., Werner F. (2009), Molecular mechanisms of archaeal RNA polymerase. 
Biochem Soc Trans. 37:12-7. doi: 10.1042/BST0370012. (externer Link, öffnet neues Fenster)

Grohmann D., Godet J., Mely Y., Darlix JL. and Restle, T. (2008). HIV-1 NC traps the reverse transcriptase on primer/template substrates. 
Biochemistry, 47:12230-40. doi: 10.1021/bi801386r (externer Link, öffnet neues Fenster).

Di Pasquale F, Fischer D, Grohmann D, Restle T, Geyer A, Marx A. (2008) Opposed steric constraints in human DNA polymerase beta and E.coli DNA polymerase I. 
J Am Chem Soc 130:10748-57. doi: 10.1021/ja8028284 (externer Link, öffnet neues Fenster).

Grohmann D., Corradi V., Horenkamp F., Laufer, S.D., Manetti, F. Botta, M. and Restle, T. (2008). Small molecule inhibitors targeting HIV-1 dimerization. 
Chembiochem 9:916-22. doi: 10.1002/cbic.200700669. (externer Link, öffnet neues Fenster)

Yamazaki S., Tan L., Mayer G., Hartig J.S., Song J.N., Reuter S., Restle T., Laufer S.D., Grohmann D., Kräusslich H.G., Bajorath J., Famulok M. (2007). Aptamer displacement identifies alternative small-molecule target sites that escape viral resistance. 
Chem Biol.14:804-12. doi: 10.1016/j.chembiol.2007.06.003. (externer Link, öffnet neues Fenster)

Mescalchin A., Wünsche W., Laufer S.D., Grohmann, D., Restle, T. and Sczakiel, G. (2006). Specific binding of a bioactive hexanucleotide to HIV-1 reverse transcriptase: a novel class of small oligomeric nucleic acid drugs. 
Nucleic Acids Research, 34, 5631–5637. doi: 10.1093/nar/gkl533 (externer Link, öffnet neues Fenster).