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University of Regensburg
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Ribosome Maturation

Ribosome Maturation 

[P.Milkereit / H.Tschochner / A.Griesenbeck]

Ribosomes catalyze the translation of mRNA into proteins and therefore play a key role in gene expression, cell growth, and cell cycle progression. Ribosomes are large ribonucleoprotein (RNP) complexes composed of ribosomal RNA (rRNA) and a large number (>50) of ribosomal proteins (r-proteins).

In recent years, detailed insights into the three-dimensional organization of rRNA and r-proteins in mature ribosomes have been gained. Moreover, it has become clear that a substantial portion of the genome of a unicellular eukaryote (baker’s yeast S. cerevisiae) encodes factors required for ribosome production. Using yeast as a model system, we investigate - employing various in vivo and in vitro approaches - the relationships between key processes in eukaryotic ribosome biogenesis, namely RNA synthesis, RNA processing, RNA folding, RNP assembly, and the intracellular transport of RNP precursors.

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