Epigenetics

(new focus subject from WS 26/27)

Organising working groups:

Note! This focus subject is new starting in the 26/27 winter semester and is therefore intended for students who begin their studies in the 26/27 winter semester. However, students who began their studies before the 26/27 winter semester may also take this module. In this case, the modules can be credited toward the focus subject Biochemistry.

Announcement! Lectur, Seminar, Lab Course in WS 26/27 and SS 27 - pdf (öffnet neues Fenster). (nicht barrierefrei)

Theory Module - Epigenetics

BIO-M-TM-EG

Detailed module description - pdf

Module coordinator: Prof. Dr. Gernot Längst

Module contents
Structure and organization of the human genome Function of the repetitive region of the genome Packaging of DNA into chromatin Molecular mechanisms of epigenetics and gene expression Presentation of current research directions and trends in epigenetics Insight into current methodical applications and approaches in epigenetics Insight into the role of epigenetics in aging processes

No.	Module component	CP	proof of academic achievement
1.	at least two lectures in the field of epigenetics (for a selection see SPUR)	6	Portfolio (collection of exercises and reflective tasks completed alongside the lectures). Please ask the module coordinator about the requirements. Once it has been finalised, the portfolio must be registered in FlexNow. The portfolio is not graded.
2.	one seminar in the field of epigenetics (for a selection see SPUR)	2	seminar presentation, regular participation You must register for the seminars. Information on how to register see in SPUR. Once you have attended a seminar, it must be registered in FlexNow. The seminar is not graded.
3.	30 min oral examination covering the entire module (graded)	4	Examiner: Prof. Dr. Gernot Längst Please get in contact with the examiner to arrange a date of the oral examination, than register the examination in Flexnow. The oral examination is graded (= module grade).

Module download:

For students starting in the winter semester 26/27 or later: BIO-M-TM-EG (pdf) (öffnet neues Fenster). (nicht barrierefrei)

Choose one practical module:

Practical Module - Chromatin Dynamics and Nuclear Architecture

BIO-M-PM-CD

Detailed module description - pdf (öffnet neues Fenster). (nicht barrierefrei)

Module coordinator: Prof. Dr. Gernot Längst

For more details see: PM Chromatin Dynamics and Nuclear Architecture

Practical Module - Computational Epigenetics

BIO-M-PM-CEG

Module coordinator: Dr. Uwe Schwartz

Module contents
Introduction to the current research area of the working group Application of workflows and pipelines for the analysis of next-generation sequencing (NGS) data Quality control, mapping, peak calling, and visualization of NGS data Use of public databases Statistical analysis of NGS data Independent theoretical work on the project Biological interpretation and critical evaluation of bioinformatic results Presentation and discussion of own experimentally generated data

Module component	CP	proof of academic achievement
Laboratory course (6 weeks): Computational Epigenetics (54222; link SPUR (externer Link, öffnet neues Fenster)) Contact the module coordinator to find a supervisor for the laboratory course. The date of the laboratory course will then be arranged with the supervisor.	12	Portfolio (graded)*

*The portfolio examination contains following:

Internship report of 4.000–10.000 words, including a bibliography,
scientific presentation (15-30 min),
practical scientific work,
data, protocols, and records -including electronic data- from scientific work, prepared in accordance with the principles of good scientific practice.

The grade of the portfolio is based on the evaluation of the report, the presentation, and the practical work in the lab. The supervisor of the laboratory course can use a template for the evaluation - Evaluation of a practical module - PDF (externer Link, öffnet neues Fenster).
The completed evaluation should then be given to the student as feedback.

Module download:

For students starting in the winter semester 26/27 or later: BIO-M-PM-CEG (pdf) (öffnet neues Fenster). (nicht barrierefrei)

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