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Human Genetics

Organising working group:

Prof. Dr. Dr. med. Davor Lessel

Link to Human Genetics at the University Hospital (externer Link, öffnet neues Fenster)

Application to the Human Genetics module

Registration by 31st of July: Frau Dr. Fabiola Biasella (Fabiola.Biasella@klinik.uni-regensburg.de)

Hinweis zur Anmeldung zum Humangenetik Modul:

Die hohe Nachfrage nach Plätzen im Mastermodul ‚Humangenetik‘ macht folgendes Prozedere erforderlich:Bitte bewerben Sie sich formell jeweils bis 31. Juli eines jeden Jahres für das kommende Wintersemester (per E-Mail an Fabiola.Biasella@klinik.uni-regensburg.de, Betreffzeile: Wahlmodul Humangenetik). Bitte fügen Sie der Bewerbung einen kurzen Lebenslauf einschließlich eines Notenspiegels erbrachter Klausur-und Prüfungsleistungen bei. Eventuell werden wir Sie im Anschluss zu einem kurzen Vorstellungsgespräch einladen. Sie erhalten bis spätestens Ende Juli verbindlich Bescheid, ob Sie in das Modul aufgenommen werden können. Wir bitten Sie, uns bis Ende August zu benachrichtigen, ob Sie den Platz annehmen möchten oder nicht. Alle nicht belegten Plätze werden dann in einem Nachrückverfahren bis Mitte September vergeben.

Application to the Human Genetics module

Due to the high demand of students to the “Human Genetics” module, a selection process takes place. Please send your application per E-Mail to Fabiola.Biasella@klinik.uni-regensburg.de with the Subject heading: Wahlmodul Humangenetik until July 31 if you want to start the module in the upcoming winter semester. The application should include a short curriculum vitae and a grade transcript. If needed, you will be invited to a short interview. Acceptance to the module will be communicated at the latest at the end of July. We request that you let us know until the end of August if you will take the module or not. Should there be free places left, these will be allotted until mid-September.

Theory Module - Human Genetics

BIO-M-TM-HG

Module coordinator: Prof. Dr. Dr. med. Davor Lessel (externer Link, öffnet neues Fenster)

Module contents

Human Genetics I – Lecture “Advanced Human Genetics” 

Comprehensive basic information on modern topics of human genetics with a strong focus on genetic variation in health and disease:

  • Organization of the human genome, gene expression and gene regulation.

  • Mendelian diseases: Basics, identification of new genetic causes, functional characterization of novel variants

  • Cancer genetics 

  • Genetics of complex diseases (e.g. functionality of genetic polymorphisms, genome wide association studies, pathway analysis), population genetics, epigenetic mechanisms, pharmacogenetics.

  • Medical genetics including basic principles of genetic counseling and diagnostics.

  • Ethical, legal, and social issues related to genetic testing.

  • Principles of gene therapy (including genome editing) and application of induced pluripotent stem cell technology. 

 

Human Genetics II – 2‑week rotation internship

This course provides deeper understanding of the impact of molecular biology and genetics on modern medicine and the connection between basic research, medical knowledge and an improved patient management. The concepts will be accompanied by theoretical introductions followed by a guided experimental course.

Topics include, but are not limited to:

 

  • Principles and specifics of modern DNA diagnostics

  • From raw data to interpretation of genetic variants

  • Cell culture and heterologous gene expression

  • Induced pluripotent stem cell technology 

  • CRISPR-Cas mediated genome editing

  • mRNA expression analysis 

  • Applications of confocal laser scanning microscopy

  • Use of disease models in human genetics research

 

Human Genetics Seminar

Presentation and discussion of a research-based topic in the field of Human Genetics

No.Module componentsCP

registration /

proof of academic achievement

1.

Lectures:

Human Genetics I

Human Genetics II (56129, link SPUR (externer Link, öffnet neues Fenster))

6

 

Students starting before the winter semester 26/27: Registration is not required for the lectures. There is no exam to sit. However, the content of the lectures may form part of the oral exam.

 

Students starting in the winter semester 26/27 or later: Portfolio (collection of exercises and reflective tasks completed alongside the lectures). Please ask the module coordinator about the requirements. Once it has been finalised, the portfolio must be registered in FlexNow.

The portfolio is not graded.

2.Human genetic literature seminar (56121, link SPUR (externer Link, öffnet neues Fenster))2

seminar presentation, regular participation

 

You must register for the seminars. Information on how to register see in SPUR.

Once you have attended a seminar, it must be registered in FlexNow.

The seminar is not graded.

3.30 min oral examination covering the entire module (graded)4

Examiners: 

Prof. Dr. Dr. med. Davor Lessel (externer Link, öffnet neues Fenster)

 

Please get in contact with the examiner of your choice to arrange a date of the oral examination, than register the examination in FlexNow.

The oral examination is graded (= module grade).

Module download pdf

For students starting before the winter semester 26/27: BIO-M-TM-HG (pdf) (öffnet neues Fenster). (nicht barrierefrei)

For students starting in the winter semester 26/27 or later: BIO-M-TM-HG (pdf) (öffnet neues Fenster). (nicht barrierefrei)

Practical Module - Human Genetics

BIO-M-PM-HG

Module coordinator: Prof. Dr. Dr. med. Davor Lessel

Module contents

  • Standard laboratory techniques in molecular biology and genetics; in-depth experimental applications including standard and advanced methodologies

  • Knowledge of and familiarization with public databases and software relevant to molecular genetics

  • Application of cell culture and animal model systems to address clinically relevant questions

  • Presentation and discussion of own data generated experimentally

  • Communication of scientific results (lectures, posters, protocols)

  • Overview of research areas in human genetics and advanced knowledge of experimental approaches in the field of molecular medical research
Module componentCPproof of academic achievement

Laboratory course (6 weeks): Human Genetics (56130, link SPUR (externer Link, öffnet neues Fenster))

 

Contact the module coordinator to find a supervisor for the laboratory course. 

The date of the laboratory course will then be arranged with the supervisor.

12Portfolio (graded)*

*The portfolio examination contains following:

  • Internship report of 4.000–10.000 words, including a bibliography, 
  • scientific presentation (15-30 min), 
  • practical scientific work, 
  • data, protocols, and records -including electronic data- from scientific work, prepared in accordance with the principles of good scientific practice. 

The grade of the portfolio is based on the evaluation of the report, the presentation, and the practical work in the lab. The supervisor of the laboratory course can use a template for the evaluation - Evaluation of a practical module - PDF. (externer Link, öffnet neues Fenster)
The completed evaluation should then be given to the student as feedback.

Module download pdf

For students starting before the winter semester 26/27: BIO-M-PM-HG (pdf) (öffnet neues Fenster). (nicht barrierefrei)

For students starting in the winter semester 26/27 or later: BIO-M-PM-HG (pdf) (öffnet neues Fenster). (nicht barrierefrei)

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