Biochemistry

Organising working groups:

Choose one Theory Module:

Theory Module - Protein Biochemistry and Enzymology

BIO-M-TM-PBE

Module coordinator: Prof. Dr Reinhard Sterner

It is recommended to simultaneously attend the practical module BIO-M-PM-PBE Protein Biochemistry and Enzymology.

Module contents
Lectures: Methods of physical biochemistry: e.g. optical spectroscopy, hydrodynamics, chromatography, electrophoresis Structure and stability of biomolecules: e.g. protein folding, protein stability, nucleic acid-protein interactions Seminar: Presentation and discussion of a research-based topic in the field of protein biochemistry and enzymology

No.	Module component	CP	registration / proof of academic achievement
1.	at least two lectures in the field of protein biochemistry and enzymology (for a selection see SPUR)*	6	Students starting before the winter semester 26/27: Registration is not required for the lectures. There is no exam to sit. However, the content of the lectures may form part of the oral exam. Students starting in the winter semester 26/27 or later: Portfolio (collection of exercises and reflective tasks completed alongside the lectures). Please ask the module coordinator about the requirements. Once it has been finalised, the portfolio must be registered in FlexNow. The portfolio is not graded.
2.	one seminar in the field of protein biochemistry and enzymology (for a selection see SPUR)*	2	seminar presentation, regular participation You must register for the seminars. Information on how to register see in SPUR. Once you have attended a seminar, it must be registered in FlexNow. The seminar is not graded.
3.	30 min oral examination covering the entire module (graded)	4	Examiners: Prof. Dr Reinhard Sterner PD Dr. Patrick Babinger Prof. Dr. Christine Ziegler The student can choose one of the examiner. Please get in contact with the examiner of your choice to arrange a date of the oral examination, than register the examination in FlexNow. The oral examination is graded (= module grade).

*Note! If you are unsure which lectures and seminars to choose, please contact the module coordinator for advice. Your choice may depend on which examiner you select for the module examination.

Module download:

For students starting before the winter semester 26/27: BIO-M-TM-PBE (pdf) (öffnet neues Fenster). (nicht barrierefrei)

For students starting in the winter semester 26/27 or later: BIO-M-TM-PBE (pdf) (öffnet neues Fenster). (nicht barrierefrei)

Theory Module - RNA Biochemistry

BIO-M-TM-RNA

Module coordinator: Prof. Dr. Gunter Meister

Module contents
Lectures: Discussion of the biogenesis and the diverse functions of coding and non-coding RNAs Introduction of the different classes of regulatory non-coding RNAs Mediation of basic knowledge in RNA-RNA, RNA-DNA and RNA-Protein interactions Presentation of current research directions in the field of RNA biochemistry/biology Insights into current methodical approaches and applications of RNA biochemistry Illustration of the role of RNA in disease and its potential therapeutic applications Seminar: Presentation and discussion of a current research-based topic in the field of RNA biochemistry/biology

No.	Module component	CP	registration / proof of academic achievement
1.	at least two lectures in the field of RNA biochemistry (for a selection see SPUR)*	6	Students starting before the winter semester 26/27: Registration is not required for the lectures. There is no exam to sit. However, the content of the lectures may form part of the oral exam. Students starting in the winter semester 26/27 or later: Portfolio (collection of exercises and reflective tasks completed alongside the lectures). Please ask the module coordinator about the requirements. Once it has been finalised, the portfolio must be registered in FlexNow. The portfolio is not graded.
2.	one seminar in the field of RNA biochemistry (for a selection see SPUR)*	2	seminar presentation, regular participation You must register for the seminars. Information on how to register see in SPUR. Once you have attended a seminar, it must be registered in FlexNow. The seminar is not graded.
3.	30 min oral examination covering the entire module (graded)	4	Examiners: Prof. Dr. Gunter Meister Prof. Dr. Gernot Längst PD Dr. Joachim Griesenbeck The student can choose one of the examiner. Please get in contact with the examiner of your choice to arrange a date of the oral examination, than register the examination in FlexNow. The oral examination is graded (= module grade).

*Note! If you are unsure which lectures and seminars to choose, please contact the module coordinator for advice. Your choice may depend on which examiner you select for the module examination.

Module download:

For students starting before the winter semester 26/27: BIO-M-TM-RNA (pdf (öffnet neues Fenster). (nicht barrierefrei))

For students starting in the winter semester 26/27 or later: BIO-M-TM-RNA (pdf) (öffnet neues Fenster). (nicht barrierefrei)

Theory Module - RNA–Protein Interactions in Time and Space

BIO-M-TM-PBE

Module coordinator: Prof. Dr. Neva Caliskan (externer Link, öffnet neues Fenster)

Note! This module is new starting in the 26/27 winter semester and is therefore intended for students who begin their studies in the 26/27 winter semester. However, students who began their studies before the 26/27 winter semester may also take this module. In this case, the modules can be credited toward the RNA Biochemistry module.

Module contents
Lectures: Methods of RNA und Protein biochemistry: e.g. fluorescence and force spectroscopy, chromatography, electrophoresis Structure and stability of biomolecules: e.g. RNA-protein folding, RNA-protein stability, nucleic acid protein interactions Seminar: Presentation and discussion of a research-based topic in the field of high resolution RNA and protein analysis

No.	Module component	CP	registration / proof of academic achievement
1.	at least two lectures in the field of Biochemistry (for a selection see SPUR)*	6	Students starting before the winter semester 26/27: Registration is not required for the lectures. There is no exam to sit. However, the content of the lectures may form part of the oral exam. Students starting in the winter semester 26/27 or later: Portfolio (collection of exercises and reflective tasks completed alongside the lectures). Please ask the module coordinator about the requirements. Once it has been finalised, the portfolio must be registered in FlexNow. The portfolio is not graded.
2.	one seminar in the field of Biochemistry (for a selection see SPUR)*	2	seminar presentation, regular participation You must register for the seminars. Information on how to register see in SPUR. Once you have attended a seminar, it must be registered in FlexNow. The seminar is not graded.
3.	30 min oral examination covering the entire module (graded)	4	Examiners: Prof. Dr. Neva Caliskan (externer Link, öffnet neues Fenster) The student can choose one of the examiner. Please get in contact with the examiner of your choice to arrange a date of the oral examination, than register the examination in FlexNow. The oral examination is graded (= module grade).

*Note! If you are unsure which lectures and seminars to choose, please contact the module coordinator for advice. Your choice may depend on which examiner you select for the module examination.

Module download:

For students starting in the winter semester 26/27 or later: BIO-M-TM-PBE (pdf) (öffnet neues Fenster). (nicht barrierefrei)

Choose one Practical Module:

Practical Module - Protein Biochemistry and Enzymology

BIO-M-PM-PBE

Module coordinator: Prof. Dr. Reinhard Sterner

It is recommended to simultaneously attend the theoretical module BIO-M-TM-PBE Protein Biochemistry and Enzymology.

Module contents
Participation in a current research project of protein biochemistry Training in planning, conducting and evaluating experiments Training in search of relevant literature Getting to know and using modern methods of protein biochemistry and enzymology Presentation and discussion of own experimentally gained data

Module component	CP	proof of academic achievement
Laboratory course (6 weeks): Protein Biochemistry and Enzymology (54191; link SPUR (externer Link, öffnet neues Fenster)) Contact the module coordinator to find a supervisor for the laboratory course. The date of the laboratory course will then be arranged with the supervisor.	12	Portfolio (graded)*

*The portfolio examination contains following:

Internship report of 4.000–10.000 words, including a bibliography,
scientific presentation (15-30 min),
practical scientific work,
data, protocols, and records -including electronic data- from scientific work, prepared in accordance with the principles of good scientific practice.

The grade of the portfolio is based on the evaluation of the report, the presentation, and the practical work in the lab. The supervisor of the laboratory course can use a template for the evaluation - Evaluation of a practical module - PDF (öffnet neues Fenster). (nicht barrierefrei).
The completed evaluation should then be given to the student as feedback.

Module download:

For students starting before the winter semester 26/27: BIO-M-PM-PBE (pdf) (öffnet neues Fenster). (nicht barrierefrei)

For students starting in the winter semester 26/27 or later: BIO-M-PM-PBE (pdf) (öffnet neues Fenster). (nicht barrierefrei)

Practical Module - RNA Biology

BIO-M-PM-RNA

Module coordinator: Prof. Dr. Gunter Meister

Module contents
Introduction into a current research field of the group Mediation of basic molecular biological and biochemical applications Consolidation of current RNA biochemical methods corresponding to the research project Independent theoretical processing of the whole project Presentation and discussion of own experimental data in a written and an oral presentation

Module component	CP	proof of academic achievement
Laboratory course (6 weeks): RNA Biology (54193; link SPUR (externer Link, öffnet neues Fenster)) Contact the module coordinator to find a supervisor for the laboratory course. The date of the laboratory course will then be arranged with the supervisor.	12	Portfolio (graded)*

*The portfolio examination contains following:

Internship report of 4.000–10.000 words, including a bibliography,
scientific presentation (15-30 min),
practical scientific work,
data, protocols, and records -including electronic data- from scientific work, prepared in accordance with the principles of good scientific practice.

The grade of the portfolio is based on the evaluation of the report, the presentation, and the practical work in the lab. The supervisor of the laboratory course can use a template for the evaluation - Evaluation of a practical module - PDF (öffnet neues Fenster) (externer Link, öffnet neues Fenster).
The completed evaluation should then be given to the student as feedback.

Module download:

For students starting before the winter semester 26/27: BIO-M-PM-RNA (pdf) (öffnet neues Fenster). (nicht barrierefrei)

For students starting in the winter semester 26/27 or later: BIO-M-PM-RNA (pdf) (öffnet neues Fenster). (nicht barrierefrei)

Practical Module - Single molecule analysis of RNA-protein complexes

BIO-M-PM-SMR

Module coordinator: Prof. Dr. Neva Caliskan (externer Link, öffnet neues Fenster)

Note! This module is new for students starting in the winter semester 26/27 or later. Students who began their studies before the winter semester 26/27 may also choose this module. In this case, it may be recognised as the RNA Biology module.

Module contents
Introduction into RNA structure analysis Introduction into single-molecule force spectroscopy and microscopy Generation fluorescence tags or reporters to monitor dynamics of RNA and protein complexes Mediation of basic molecular biological and biochemical applications Consolidation of biochemical and single molecule analysis methods corresponding to the research project Independent theoretical processing of the whole project Presentation and discussion of own experimental data in a written and an oral presentation

Module component	CP	proof of academic achievement
Laboratory course (6 weeks): Single molecule analysis of RNA-protein complexes (54236; link SPUR (externer Link, öffnet neues Fenster)) Contact the module coordinator to find a supervisor for the laboratory course. The date of the laboratory course will then be arranged with the supervisor.	12	Portfolio (graded)*

*The portfolio examination contains following:

Internship report of 4.000–10.000 words, including a bibliography,
scientific presentation (15-30 min),
practical scientific work,
data, protocols, and records -including electronic data- from scientific work, prepared in accordance with the principles of good scientific practice.

The grade of the portfolio is based on the evaluation of the report, the presentation, and the practical work in the lab. The supervisor of the laboratory course can use a template for the evaluation - Evaluation of a practical module - PDF (externer Link, öffnet neues Fenster).
The completed evaluation should then be given to the student as feedback.

Module download:

For students starting in the winter semester 26/27 or later: BIO-M-PM-SMR (pdf) (öffnet neues Fenster). (nicht barrierefrei)

Practical Module - Chromatin Dynamics and Nuclear Architecture

BIO-M-PM-CD

Module coordinator: Prof. Dr. Gernot Längst

Module contents
Functional analysis of chromatin modifying enzymes in vitro and in vivo. Characterisation of the chromatin structures and dynamic mechanisms in human and murine cells and as well in the Malaria causing parasite Plasmodium falciparum. Determining the mechanism of sequence specific DNA access in chromatin and characterisation of the genome architecture by high throughput sequencing methods and bioinformatics. Functional characterisation of non-coding RNA binding to chromatin. Sequence specific binding of non-coding RNA to DNA via the formation of triple helices. Quantification of molecular interactions by the microscale thermophoresis method. Presentation and discussion of own experimental gained data

Module component	CP	proof of academic achievement
Laboratory course (6 weeks): Chromatin Dynamics and Nuclear Architecture (54195; link SPUR (externer Link, öffnet neues Fenster)) Contact the module coordinator to find a supervisor for the laboratory course. The date of the laboratory course will then be arranged with the supervisor.	12	Portfolio (graded)*

*The portfolio examination contains following:

Internship report of 4.000–10.000 words, including a bibliography,
scientific presentation (15-30 min),
practical scientific work,
data, protocols, and records -including electronic data- from scientific work, prepared in accordance with the principles of good scientific practice.

The grade of the portfolio is based on the evaluation of the report, the presentation, and the practical work in the lab. The supervisor of the laboratory course can use a template for the evaluation - Evaluation of a practical module - PDF (externer Link, öffnet neues Fenster).
The completed evaluation should then be given to the student as feedback.

Module download:

For students starting before the winter semester 26/27: BIO-M-PM-CD (pdf) (öffnet neues Fenster). (nicht barrierefrei)

For students starting in the winter semester 26/27 or later: BIO-M-PM-CD (pdf) (öffnet neues Fenster). (nicht barrierefrei)

Practical Module - Ribosome Biogenesis

BIO-M-PM-RB

Module coordinator: Prof. Dr. Joachim Griesenbeck, Dr. Philipp Milkereit

Module contents
In vivo, ex vivo and in vitro experiments to study ribosome biogenesis in the model organism S. cerevisiae and in archaea, for example Analysis of the RNA polymerase I transcription machinery Analysis of rDNA chromatin Assembly of pre-ribosomes Possibilities exist to use cellbiological, genetic and biochemical approaches to analyse synthesis and processing of RNA, structure and function of chromatin as well as mass spectrometric proteom analyses Presentation and discussion of own experimental gained data

Module component	CP	proof of academic achievement
Laboratory course (6 weeks): Ribosome Biogenesis (54192; link SPUR (externer Link, öffnet neues Fenster)) Contact the module coordinator to find a supervisor for the laboratory course. The date of the laboratory course will then be arranged with the supervisor.	12	Portfolio (graded)*

*The portfolio examination contains following:

Internship report of 4.000–10.000 words, including a bibliography,
scientific presentation (15-30 min),
practical scientific work,
data, protocols, and records -including electronic data- from scientific work, prepared in accordance with the principles of good scientific practice.

The grade of the portfolio is based on the evaluation of the report, the presentation, and the practical work in the lab. The supervisor of the laboratory course can use a template for the evaluation - Evaluation of a practical module - PDF (externer Link, öffnet neues Fenster).
The completed evaluation should then be given to the student as feedback.

Module download:

For students starting before the winter semester 26/27: BIO-M-PM-RB (pdf (öffnet neues Fenster). (nicht barrierefrei))

For students starting in the winter semester 26/27 or later: BIO-M-PM-RB (pdf) (öffnet neues Fenster). (nicht barrierefrei)

Practical Module - Structural Biochemistry

BIO-M-PM-SB

Module coordinator: Prof. Dr. Christoph Engel (externer Link, öffnet neues Fenster)

Module contents
Cloning, expression, and purification of proteins, multi-protein complexes, and protein–DNA/RNA complexes Functional and structural characterization Single-particle cryo-electron microscopy Data processing Structural biology modeling AI-driven structure prediction and experimental validation Presentation and discussion of own experimental gained data

Module component	CP	proof of academic achievement
Laboratory course (6 weeks): Structural Biochemistry (54256; link SPUR (externer Link, öffnet neues Fenster)) Contact the module coordinator to find a supervisor for the laboratory course. The date of the laboratory course will then be arranged with the supervisor.	12	Portfolio (graded)*

*The portfolio examination contains following:

Internship report of 4.000–10.000 words, including a bibliography,
scientific presentation (15-30 min),
practical scientific work,
data, protocols, and records -including electronic data- from scientific work, prepared in accordance with the principles of good scientific practice.

The grade of the portfolio is based on the evaluation of the report, the presentation, and the practical work in the lab. The supervisor of the laboratory course can use a template for the evaluation - Evaluation of a practical module - PDF (externer Link, öffnet neues Fenster).
The completed evaluation should then be given to the student as feedback.

Module download:

For students starting in the winter semester 26/27 or later: BIO-M-PM-SB (pdf) (öffnet neues Fenster). (nicht barrierefrei)

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