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• "BiCoN: network-constrained biclustering of patients and omics data", Lazareva, Canzar, Yuan, Baumbach, Blumenthal, Tieri, Kacprowski, List, Valencia, 2020

  Publikation

  MotivationUnsupervised learning approaches are frequently used to stratify patients into clinically relevant subgroups and to identify biomarkers...

  Publikation auf epub.uni-regensburg.de: "BiCoN: network-constrained biclustering of patients and omics data" (externer Link, öffnet neues Fenster)

• "Linear-time cluster ensembles of large-scale single-cell RNA-seq and multimodal data", Do, Rojas Ringeling, Canzar, 2021

  Publikation

  A fundamental task in single-cell RNA-seq (scRNA-seq) analysis is the identification of transcriptionally distinct groups of cells. Numerous methods...

  Publikation auf epub.uni-regensburg.de: "Linear-time cluster ensembles of large-scale single-cell RNA-seq and multimodal data" (externer Link, öffnet neues Fenster)

• "McSplicer: a probabilistic model for estimating splice site usage from RNA-seq data", Alqassem, Sonthalia, Klitzke-Feser, Shim, Canzar, 2021

  Publikation

  MotivationAlternative splicing removes intronic sequences from pre-mRNAs in alternative ways to produce different forms (isoforms) of mature mRNA....

  Publikation auf epub.uni-regensburg.de: "McSplicer: a probabilistic model for estimating splice site usage from RNA-seq data" (externer Link, öffnet neues Fenster)

• "A generalization of t-SNE and UMAP to single-cell multimodal omics", Do, Canzar, 2021

  Publikation

  Emerging single-cell technologies profile multiple types of molecules within individual cells. A fundamental step in the analysis of the produced...

  Publikation auf epub.uni-regensburg.de: "A generalization of t-SNE and UMAP to single-cell multimodal omics" (externer Link, öffnet neues Fenster)

• "CYFIP1 Dosages Exhibit Divergent Behavioral Impact via Diametric Regulation of NMDA Receptor Complex Translation in Mouse Models of Psychiatric Disorders", Kim, Ringeling, Zhou, Nguyen, Temme, Lin, Eacker, Dawson, Dawson, Xiao, Hsu, Canzar, Li, Worley, Christian, Yoon, Song, Ming, 2021

  Publikation

  BackgroundGene dosage imbalance caused by copy number variations (CNVs) is a prominent contributor to brain disorders. In particular, 15q11.2 CNV...

  Publikation auf epub.uni-regensburg.de: "CYFIP1 Dosages Exhibit Divergent Behavioral Impact via Diametric Regulation of NMDA Receptor Complex Translation in Mouse Models of Psychiatric Disorders" (externer Link, öffnet neues Fenster)

• "Partitioning RNAs by length improves transcriptome reconstruction from short-read RNA-seq data", Ringeling, Chakraborty, Vissers, Reiman, Patel, Lee, Hong, Park, Reska, Gagneur, Chang, Spletter, Yoon, Ming, Song, Canzar, 2022

  Publikation

  The accuracy of methods for assembling transcripts from short-read RNA sequencing data is limited by the lack of long-range information. Here we...

  Publikation auf epub.uni-regensburg.de: "Partitioning RNAs by length improves transcriptome reconstruction from short-read RNA-seq data" (externer Link, öffnet neues Fenster)

• "Predicting RNA splicing branchpoints", Jovanovic, Alqassem, Chappell, Canzar, Matijević, 2022

  Publikation

  RNA splicing is a process where introns are removed from pre-mRNA, resulting in mature mRNA. It requires three main signals, a donor splice site...

  Publikation auf epub.uni-regensburg.de: "Predicting RNA splicing branchpoints" (externer Link, öffnet neues Fenster)

• "The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells", Ito-Kureha, Leoni, Borland, Cantini, Bataclan, Metzger, Ammann, Krug, Marsico, Kaiser, Canzar, Feske, Monticelli, König, Heissmeyer, 2022

  Publikation

  Nature Immunology 1529-2916,1529-2908 10.1038/s41590-022-01268-1

  Publikation auf epub.uni-regensburg.de: "The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells" (externer Link, öffnet neues Fenster)

• "Genome‐wide off‐target analyses of CRISPR/Cas9‐mediated T‐cell receptor engineering in primary human T cells", Kaeuferle, Stief, Canzar, Kutlu, Willier, Stenger, Ferrada‐Ernst, Habjan, Peters, Busch, Feuchtinger, 2022

  Publikation

  ObjectivesExploiting the forces of human T cells for treatment has led to the current paradigm of emerging immunotherapy strategies. Genetic...

  Publikation auf epub.uni-regensburg.de: "Genome‐wide off‐target analyses of CRISPR/Cas9‐mediated T‐cell receptor engineering in primary human T cells" (externer Link, öffnet neues Fenster)

• "Ccr4–Not complex reduces transcription efficiency in heterochromatin", Monteagudo-Mesas, Brönner, Kohvaei, Amedi, Canzar, Halic, 2022

  Publikation

  Heterochromatic silencing is thought to occur through a combination of transcriptional silencing and RNA degradation, but the relative contribution of...

  Publikation auf epub.uni-regensburg.de: "Ccr4–Not complex reduces transcription efficiency in heterochromatin" (externer Link, öffnet neues Fenster)