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Suchergebnisse

• "Stabilisation of a (betaalpha)8-barrel protein designed from identical half barrels.", Seitz, Bocola, Claren, Sterner, 2007

  Publikation

  It has been suggested that the common (beta alpha)(8)-barrel enzyme fold has evolved by the duplication and fusion of identical (beta alpha)-half...

  Publikation auf epub.uni-regensburg.de: "Stabilisation of a (betaalpha)8-barrel protein designed from identical half barrels." (externer Link, öffnet neues Fenster)

• "A rationally designed monomeric variant of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus is as active as the dimeric wild-type enzyme but less thermostable.", Schwab, Skegro, Mayans, Sterner, 2008

  Publikation

  The anthranilate phosphoribosyltransferase from Sulfolobus solfataricus (ssAnPRT) forms a homodimer with a hydrophobic subunit interface. To elucidate...

  Publikation auf epub.uni-regensburg.de: "A rationally designed monomeric variant of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus is as active as the dimeric wild-type enzyme but less thermostable." (externer Link, öffnet neues Fenster)

• "A robust protein host for anchoring chelating ligands and organocatalysts.", Reetz, Rentzsch, Pletsch, Taglieber, Hollmann, Mondière, Dickmann, Höcker, Cerrone, Haeger, Sterner, 2008

  Publikation

  In order to put the previously proposed concept of directed evolution of hybrid catalysts (proteins that harbor synthetic transition-metal catalysts...

  Publikation auf epub.uni-regensburg.de: "A robust protein host for anchoring chelating ligands and organocatalysts." (externer Link, öffnet neues Fenster)

• "Identification and characterization of a bacterial glycerol-1-phosphate dehydrogenase: Ni(2+)-dependent AraM from Bacillus subtilis.", Guldan, Sterner, Babinger, 2008

  Publikation

  The exclusive presence of glycerol-1-phosphate dehydrogenases (G1PDH) has been postulated to be a key feature that distinguishes archaea from...

  Publikation auf epub.uni-regensburg.de: "Identification and characterization of a bacterial glycerol-1-phosphate dehydrogenase: Ni(2+)-dependent AraM from Bacillus subtilis." (externer Link, öffnet neues Fenster)

• "Computational design of enzymes", Sterner, Merkl, Raushel, 2008

  Publikation

  The de novo design of enzymes with activities not found in natural biocatalysts is a major challenge for molecular biology. Sophisticated...

  Publikation auf epub.uni-regensburg.de: "Computational design of enzymes" (externer Link, öffnet neues Fenster)

• "Functional annotation and three-dimensional structure of Dr0930 from Deinococcus radiodurans, a close relative of phosphotriesterase in the amidohydrolase superfamily.", Xiang, Kolb, Fedorov, Meier, Fedorov, Nguyen, Sterner, Almo, Shoichet, Raushel, 2009

  Publikation

  Dr0930, a member of the amidohydrolase superfamily in Deinococcus radiodurans, was cloned, expressed, and purified to homogeneity. The enzyme...

  Publikation auf epub.uni-regensburg.de: "Functional annotation and three-dimensional structure of Dr0930 from Deinococcus radiodurans, a close relative of phosphotriesterase in the amidohydrolase superfamily." (externer Link, öffnet neues Fenster)

• "Activation of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus by removal of magnesium inhibition and acceleration of product release", Schlee, Deuss, Bruning, Ivens, Schwab, Hellmann, Mayans, Sterner, 2009

  Publikation

  Anthranilate phosphoribosyltransferase from the hyperthermophilic archaeon Sulfolobus solfataricus (ssAnPRT) is encoded by the sstrpD gene and...

  Publikation auf epub.uni-regensburg.de: "Activation of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus by removal of magnesium inhibition and acceleration of product release" (externer Link, öffnet neues Fenster)

• "High-resolution crystal structure of an artificial (betaalpha)(8)-barrel protein designed from identical half-barrels.", Höcker, Lochner, Seitz, Claren, Sterner, 2009

  Publikation

  Ample evidence suggests that the ubiquitous (beta alpha)(8)-barrel enzyme fold has evolved by the duplication and fusion of an ancestral (beta...

  Publikation auf epub.uni-regensburg.de: "High-resolution crystal structure of an artificial (betaalpha)(8)-barrel protein designed from identical half-barrels." (externer Link, öffnet neues Fenster)

• "TransCent: computational enzyme design by transferring active sites and considering constraints relevant for catalysis", Fischer, Enkler, Neudert, Bocola, Sterner, Merkl, 2009

  Publikation

  Background: Computational enzyme design is far from being applicable for the general case. Due to computational complexity and limited knowledge of...

  Publikation auf epub.uni-regensburg.de: "TransCent: computational enzyme design by transferring active sites and considering constraints relevant for catalysis" (externer Link, öffnet neues Fenster)

• "Kinetic Mechanism of Indole-3-glycerol Phosphate Synthase", Schlee, Dietrich, Kurćon, Delaney, Goodey, Sterner, 2013

  Publikation

  The (beta alpha)(8)-barrel enzyme indole-3-glycerol phosphate synthase (IGPS) catalyzes the multistep transformation of...

  Publikation auf epub.uni-regensburg.de: "Kinetic Mechanism of Indole-3-glycerol Phosphate Synthase" (externer Link, öffnet neues Fenster)