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Suchergebnisse

• "Structural and Mutational Analysis of Substrate Complexation by Anthranilate Phosphoribosyltransferase from Sulfolobus solfataricus", Marino, Deuss, Svergun, Konarev, Sterner, Mayans, 2006

  Publikation

  The metabolic synthesis and degradation of essential nucleotide compounds are primarily carried out by phosphoribosyltransferases (PRT) and nucleoside...

  Publikation auf epub.uni-regensburg.de: "Structural and Mutational Analysis of Substrate Complexation by Anthranilate Phosphoribosyltransferase from Sulfolobus solfataricus" (externer Link, öffnet neues Fenster)

• "Stabilisation of a (betaalpha)8-barrel protein designed from identical half barrels.", Seitz, Bocola, Claren, Sterner, 2007

  Publikation

  It has been suggested that the common (beta alpha)(8)-barrel enzyme fold has evolved by the duplication and fusion of identical (beta alpha)-half...

  Publikation auf epub.uni-regensburg.de: "Stabilisation of a (betaalpha)8-barrel protein designed from identical half barrels." (externer Link, öffnet neues Fenster)

• "A rationally designed monomeric variant of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus is as active as the dimeric wild-type enzyme but less thermostable.", Schwab, Skegro, Mayans, Sterner, 2008

  Publikation

  The anthranilate phosphoribosyltransferase from Sulfolobus solfataricus (ssAnPRT) forms a homodimer with a hydrophobic subunit interface. To elucidate...

  Publikation auf epub.uni-regensburg.de: "A rationally designed monomeric variant of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus is as active as the dimeric wild-type enzyme but less thermostable." (externer Link, öffnet neues Fenster)

• "A robust protein host for anchoring chelating ligands and organocatalysts.", Reetz, Rentzsch, Pletsch, Taglieber, Hollmann, Mondière, Dickmann, Höcker, Cerrone, Haeger, Sterner, 2008

  Publikation

  In order to put the previously proposed concept of directed evolution of hybrid catalysts (proteins that harbor synthetic transition-metal catalysts...

  Publikation auf epub.uni-regensburg.de: "A robust protein host for anchoring chelating ligands and organocatalysts." (externer Link, öffnet neues Fenster)

• "Identification and characterization of a bacterial glycerol-1-phosphate dehydrogenase: Ni(2+)-dependent AraM from Bacillus subtilis.", Guldan, Sterner, Babinger, 2008

  Publikation

  The exclusive presence of glycerol-1-phosphate dehydrogenases (G1PDH) has been postulated to be a key feature that distinguishes archaea from...

  Publikation auf epub.uni-regensburg.de: "Identification and characterization of a bacterial glycerol-1-phosphate dehydrogenase: Ni(2+)-dependent AraM from Bacillus subtilis." (externer Link, öffnet neues Fenster)

• "Computational design of enzymes", Sterner, Merkl, Raushel, 2008

  Publikation

  The de novo design of enzymes with activities not found in natural biocatalysts is a major challenge for molecular biology. Sophisticated...

  Publikation auf epub.uni-regensburg.de: "Computational design of enzymes" (externer Link, öffnet neues Fenster)

• "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases", Semmelmann, Hupfeld, Heizinger, Merkl, Sterner, 2019

  Publikation

  The members of the glutamine amidotransferase (GATase) family catalyze the incorporation of ammonia within numerous metabolic pathways and can be...

  Publikation auf epub.uni-regensburg.de: "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases" (externer Link, öffnet neues Fenster)

• "Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction", Schupfner, Straub, Busch, Merkl, Sterner, 2019

  Publikation

  Tryptophan synthase (TS) is a heterotetrameric alpha beta beta alpha complex. It is characterized by the channeling of the reaction intermediate...

  Publikation auf epub.uni-regensburg.de: "Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction" (externer Link, öffnet neues Fenster)

• "Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint", Schupfner, Busch, Wysocki, Sterner, 2019

  Publikation

  The alpha beta beta alpha tryptophan synthase (TS), which is part of primary metabolism, is a paradigm for allosteric communication in multienzyme...

  Publikation auf epub.uni-regensburg.de: "Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint" (externer Link, öffnet neues Fenster)

• "Prediction of quaternary structure by analysis of hot spot residues in protein‐protein interfaces: the case of anthranilate phosphoribosyltransferases", Schlee, Straub, Schwab, Kinateder, Merkl, Sterner, 2019

  Publikation

  It is an important goal of computational biology to correctly predict the association state of a protein based on its amino acid sequence and the...

  Publikation auf epub.uni-regensburg.de: "Prediction of quaternary structure by analysis of hot spot residues in protein‐protein interfaces: the case of anthranilate phosphoribosyltransferases" (externer Link, öffnet neues Fenster)