Suche

Suchergebnisse

• "Computational and Experimental Evidence for the Evolution of a (betaalpha)(8)-Barrel Protein from an Ancestral Quarter-Barrel Stabilised by Disulfide Bonds", Richter, Bosnali, Carstensen, Seitz, Durchschlag, Blanquart, Merkl, Sterner, 2010

  Publikation

  The evolution of the prototypical (beta alpha)(8)-barrel protein imidazole glycerol phosphate synthase (HisF) was studied by complementary...

  Publikation auf epub.uni-regensburg.de: "Computational and Experimental Evidence for the Evolution of a (betaalpha)(8)-Barrel Protein from an Ancestral Quarter-Barrel Stabilised by Disulfide Bonds" (externer Link, öffnet neues Fenster)

• "Stabilization of a Metabolic Enzyme by Library Selection in Thermus thermophilus", Schwab, Sterner, 2011

  Publikation

  The anthranilate phosphoribosyl transferase from the hyper-thermophilic archaeon Sulfolobus solfataricus (sAnPRT, encoded by strpD), which catalyzes...

  Publikation auf epub.uni-regensburg.de: "Stabilization of a Metabolic Enzyme by Library Selection in Thermus thermophilus" (externer Link, öffnet neues Fenster)

• "Related (βα)8‐Barrel Proteins in Histidine and Tryptophan Biosynthesis: A Paradigm to Study Enzyme Evolution", List, Sterner, Wilmanns, 2011

  Publikation

  ChemBioChem 1439-4227,1439-4227 10.1002/cbic.201100082

  Publikation auf epub.uni-regensburg.de: "Related (βα)8‐Barrel Proteins in Histidine and Tryptophan Biosynthesis: A Paradigm to Study Enzyme Evolution" (externer Link, öffnet neues Fenster)

• "Functional Assignment of an Enzyme that Catalyzes the Synthesis of an Archaea-Type Ether Lipid in Bacteria", Guldan, Matysik, Bocola, Sterner, Babinger, 2011

  Publikation

  Angewandte Chemie International Edition 10.1002/anie.201101832

  Publikation auf epub.uni-regensburg.de: "Functional Assignment of an Enzyme that Catalyzes the Synthesis of an Archaea-Type Ether Lipid in Bacteria" (externer Link, öffnet neues Fenster)

• "A Fast and Precise Approach for Computational Saturation Mutagenesis and its Experimental Validation by Using an Artificial (βα)8-Barrel Protein", Fischer, Seitz, Lochner, Sterner, Merkl, Bocola, 2011

  Publikation

  We present a computational saturation mutagenesis protocol (CoSM) that predicts the impact on stability of all possible amino acid substitutions for a...

  Publikation auf epub.uni-regensburg.de: "A Fast and Precise Approach for Computational Saturation Mutagenesis and its Experimental Validation by Using an Artificial (βα)8-Barrel Protein" (externer Link, öffnet neues Fenster)

• "A sugar isomerization reaction established on various ( )8-barrel scaffolds is based on substrate-assisted catalysis", Reisinger, Bocola, List, Claren, Rajendran, Sterner, 2012

  Publikation

  In the course of tryptophan biosynthesis, the isomerization of phosphoribosylanthranilate (PRA) is catalyzed by the (beta alpha)(8)-barrel enzyme...

  Publikation auf epub.uni-regensburg.de: "A sugar isomerization reaction established on various ( )8-barrel scaffolds is based on substrate-assisted catalysis" (externer Link, öffnet neues Fenster)

• "Dimerization determines substrate specificity of a bacterial prenyltransferase", Peterhoff, Zellner, Guldan, Merkl, Sterner, Babinger, 2012

  Publikation

  We have identified the native dimer interface of heptaprenylglyceryl phosphate synthase PcrB from the bacterium Bacillus subtilis and analyzed the...

  Publikation auf epub.uni-regensburg.de: "Dimerization determines substrate specificity of a bacterial prenyltransferase" (externer Link, öffnet neues Fenster)

• "Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site", List, Vega, Razeto, Häger, Sterner, Wilmanns, 2012

  Publikation

  Nitrogen is incorporated into various metabolites by multifunctional glutamine amidotransferases via reactive ammonia generated by glutaminase...

  Publikation auf epub.uni-regensburg.de: "Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site" (externer Link, öffnet neues Fenster)

• "Constitutively Active Glutaminase Variants Provide Insights into the Activation Mechanism of Anthranilate Synthase", List, Bocola, Haeger, Sterner, 2012

  Publikation

  The glutamine amidotransferase (GATase) family comprises enzyme complexes which consist of glutaminase and synthase subunits that catalyze in a...

  Publikation auf epub.uni-regensburg.de: "Constitutively Active Glutaminase Variants Provide Insights into the Activation Mechanism of Anthranilate Synthase" (externer Link, öffnet neues Fenster)

• "Directed evolution of ( )8-barrel enzymes: establishing phosphoribosylanthranilate isomerisation activity on the scaffold of the tryptophan synthase -subunit", Evran, Telefoncu, Sterner, 2012

  Publikation

  Phosphoribosylanthranilate (PRA) isomerase (TrpF) and tryptophan synthase -subunit (TrpA) are ()(8)-barrel enzymes that are involved in the...

  Publikation auf epub.uni-regensburg.de: "Directed evolution of ( )8-barrel enzymes: establishing phosphoribosylanthranilate isomerisation activity on the scaffold of the tryptophan synthase -subunit" (externer Link, öffnet neues Fenster)