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• "Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia", Semmelmann, Kabeya, Malcicka, Bruckmann, Broschwitz, Straub, Merkl, Monroig, Sterner, Ruther, Ellers, 2019

  Publikation

  Insect pheromones are often derived from fatty acid metabolism. Fatty acid desaturases, enzymes introducing double bonds into fatty acids, are crucial...

  Publikation auf epub.uni-regensburg.de: "Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia" (externer Link, öffnet neues Fenster)

• "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases", Semmelmann, Hupfeld, Heizinger, Merkl, Sterner, 2019

  Publikation

  The members of the glutamine amidotransferase (GATase) family catalyze the incorporation of ammonia within numerous metabolic pathways and can be...

  Publikation auf epub.uni-regensburg.de: "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases" (externer Link, öffnet neues Fenster)

• "Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction", Schupfner, Straub, Busch, Merkl, Sterner, 2019

  Publikation

  Tryptophan synthase (TS) is a heterotetrameric alpha beta beta alpha complex. It is characterized by the channeling of the reaction intermediate...

  Publikation auf epub.uni-regensburg.de: "Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction" (externer Link, öffnet neues Fenster)

• "Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint", Schupfner, Busch, Wysocki, Sterner, 2019

  Publikation

  The alpha beta beta alpha tryptophan synthase (TS), which is part of primary metabolism, is a paradigm for allosteric communication in multienzyme...

  Publikation auf epub.uni-regensburg.de: "Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint" (externer Link, öffnet neues Fenster)

• "Prediction of quaternary structure by analysis of hot spot residues in protein‐protein interfaces: the case of anthranilate phosphoribosyltransferases", Schlee, Straub, Schwab, Kinateder, Merkl, Sterner, 2019

  Publikation

  It is an important goal of computational biology to correctly predict the association state of a protein based on its amino acid sequence and the...

  Publikation auf epub.uni-regensburg.de: "Prediction of quaternary structure by analysis of hot spot residues in protein‐protein interfaces: the case of anthranilate phosphoribosyltransferases" (externer Link, öffnet neues Fenster)

• "Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids", Kneuttinger, Straub, Bittner, Simeth, Bruckmann, Busch, Rajendran, Hupfeld, Wysocki, Horinek, König, Merkl, Sterner, 2019

  Publikation

  Imidazole glycerol phosphate synthase (ImGPS) is an allosteric bienzyme complex in which substrate binding to the synthase subunit HisF stimulates the...

  Publikation auf epub.uni-regensburg.de: "Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids" (externer Link, öffnet neues Fenster)

• "Mapping key amino acid residues for the epimerase efficiency and stereospecificity of the sex pheromone biosynthetic short-chain dehydrogenases/reductases of Nasonia", Semmelmann, Hofferberth, Ruther, Sterner, 2019

  Publikation

  Males of the parasitic wasp genus Nasonia use blends of chiral hydroxylactones as sex pheromones to attract conspecific females. Whereas all Nasonia...

  Publikation auf epub.uni-regensburg.de: "Mapping key amino acid residues for the epimerase efficiency and stereospecificity of the sex pheromone biosynthetic short-chain dehydrogenases/reductases of Nasonia" (externer Link, öffnet neues Fenster)

• "Library Selection with a Randomized Repertoire of (βα)8-Barrel Enzymes Results in Unexpected Induction of Gene Expression", Rohweder, Lehmann, Eichner, Polen, Rajendran, Ruperti, Linde, Treiber, Jung, Dettmer, Meister, Bott, Gronwald, Sterner, 2019

  Publikation

  The potential of the frequently encountered (beta alpha)(8)-barrel fold to acquire new functions was tested by an approach combining random...

  Publikation auf epub.uni-regensburg.de: "Library Selection with a Randomized Repertoire of (βα)8-Barrel Enzymes Results in Unexpected Induction of Gene Expression" (externer Link, öffnet neues Fenster)

• "Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology", Kneuttinger, Zwisele, Straub, Bruckmann, Busch, Kinateder, Gaim, Wysocki, Merkl, Sterner, 2019

  Publikation

  The spatiotemporal control of enzymes by light is of growing importance for industrial biocatalysis. Within this context, the photo-control of...

  Publikation auf epub.uni-regensburg.de: "Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology" (externer Link, öffnet neues Fenster)

• "Quaternary Structure of the Tryptophan Synthase α-Subunit Homolog BX1 from Zea mays", Norris, Busch, Schupfner, Sterner, Wysocki, 2020

  Publikation

  BX1 from Zea mays (zmBX1) is an enzyme of plant secondary metabolism that generates indole for the synthesis of plant defensins. It is a homologue of...

  Publikation auf epub.uni-regensburg.de: "Quaternary Structure of the Tryptophan Synthase α-Subunit Homolog BX1 from Zea mays" (externer Link, öffnet neues Fenster)