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• "Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures", Linde, Heyn, Merkl, Sterner, Babinger, 2018

  Publikation

  The cell membranes of all archaea contain ether lipids, and a number of archaea are hyperthermophilic. Consequently, the enzymes that catalyze the...

  Publikation auf epub.uni-regensburg.de: "Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures" (externer Link, öffnet neues Fenster)

• "Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand", Kneuttinger, Winter, Simeth, Heyn, Merkl, König, Sterner, 2018

  Publikation

  The artificial regulation of proteins by light is an emerging subdiscipline of synthetic biology. Here, we used this concept to photocontrol both...

  Publikation auf epub.uni-regensburg.de: "Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand" (externer Link, öffnet neues Fenster)

• "Mapping key amino acid residues for the epimerase efficiency and stereospecificity of the sex pheromone biosynthetic short-chain dehydrogenases/reductases of Nasonia", Semmelmann, Hofferberth, Ruther, Sterner, 2019

  Publikation

  Males of the parasitic wasp genus Nasonia use blends of chiral hydroxylactones as sex pheromones to attract conspecific females. Whereas all Nasonia...

  Publikation auf epub.uni-regensburg.de: "Mapping key amino acid residues for the epimerase efficiency and stereospecificity of the sex pheromone biosynthetic short-chain dehydrogenases/reductases of Nasonia" (externer Link, öffnet neues Fenster)

• "Library Selection with a Randomized Repertoire of (βα)8-Barrel Enzymes Results in Unexpected Induction of Gene Expression", Rohweder, Lehmann, Eichner, Polen, Rajendran, Ruperti, Linde, Treiber, Jung, Dettmer, Meister, Bott, Gronwald, Sterner, 2019

  Publikation

  The potential of the frequently encountered (beta alpha)(8)-barrel fold to acquire new functions was tested by an approach combining random...

  Publikation auf epub.uni-regensburg.de: "Library Selection with a Randomized Repertoire of (βα)8-Barrel Enzymes Results in Unexpected Induction of Gene Expression" (externer Link, öffnet neues Fenster)

• "Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology", Kneuttinger, Zwisele, Straub, Bruckmann, Busch, Kinateder, Gaim, Wysocki, Merkl, Sterner, 2019

  Publikation

  The spatiotemporal control of enzymes by light is of growing importance for industrial biocatalysis. Within this context, the photo-control of...

  Publikation auf epub.uni-regensburg.de: "Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology" (externer Link, öffnet neues Fenster)

• "Quaternary Structure of the Tryptophan Synthase α-Subunit Homolog BX1 from Zea mays", Norris, Busch, Schupfner, Sterner, Wysocki, 2020

  Publikation

  BX1 from Zea mays (zmBX1) is an enzyme of plant secondary metabolism that generates indole for the synthesis of plant defensins. It is a homologue of...

  Publikation auf epub.uni-regensburg.de: "Quaternary Structure of the Tryptophan Synthase α-Subunit Homolog BX1 from Zea mays" (externer Link, öffnet neues Fenster)

• "Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole", Fleming, Schupfner, Busch, Baslé, Ehrmann, Sterner, Mayans, 2018

  Publikation

  Tryptophan synthase (TrpS) is a heterotetrameric alpha beta beta alpha enzyme that exhibits complex substrate channeling and allosteric mechanisms and...

  Publikation auf epub.uni-regensburg.de: "Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole" (externer Link, öffnet neues Fenster)

• "Mapping the Allosteric Communication Network of Aminodeoxychorismate Synthase", Semmelmann, Straub, Nazet, Rajendran, Merkl, Sterner, 2019

  Publikation

  Allosteric communication between different subunits in metabolic enzyme complexes is of utmost physiological importance but only understood for few...

  Publikation auf epub.uni-regensburg.de: "Mapping the Allosteric Communication Network of Aminodeoxychorismate Synthase" (externer Link, öffnet neues Fenster)

• "Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia", Semmelmann, Kabeya, Malcicka, Bruckmann, Broschwitz, Straub, Merkl, Monroig, Sterner, Ruther, Ellers, 2019

  Publikation

  Insect pheromones are often derived from fatty acid metabolism. Fatty acid desaturases, enzymes introducing double bonds into fatty acids, are crucial...

  Publikation auf epub.uni-regensburg.de: "Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia" (externer Link, öffnet neues Fenster)

• "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases", Semmelmann, Hupfeld, Heizinger, Merkl, Sterner, 2019

  Publikation

  The members of the glutamine amidotransferase (GATase) family catalyze the incorporation of ammonia within numerous metabolic pathways and can be...

  Publikation auf epub.uni-regensburg.de: "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases" (externer Link, öffnet neues Fenster)