Firms regularly replace their old product generation by a newer generation to sustain and increase their market share and profit. The product rollover...
The overall significance of loop motions for enzymatic activity is generally accepted. However, it has largely remained unclear whether and how such...
The external control of catalytic activity and substrate specificity of enzymes by light has aroused great interest in the fields of biocatalysis and...
Allosteric regulation of catalytic activity is a widespread property of multi-enzyme complexes. The tryptophan synthase is a prototypical allosteric...
The sequencing of numerous genomes has led to the identification of open reading frames for millions of enzymes, many of which use unknown substrates....
We present a detailed structure-function analysis of the ureidoacrylate amidohydrolase RutB from Eschericha coli, which is an essential enzyme of the...
The mechanisms underlying the rapid evolution of novel enzymatic activities from promiscuous side activities are poorly understood. Recently emerged...
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