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• "Rosetta:MSF: a modular framework for multi-state computational protein design", Merkl, Löffler, Schmitz, Hupfeld, Sterner, 2017

  Publikation

  Computational protein design (CPD) is a powerful technique to engineer existing proteins or to design novel ones that display desired properties....

  Publikation auf epub.uni-regensburg.de: "Rosetta:MSF: a modular framework for multi-state computational protein design" (externer Link, öffnet neues Fenster)

• "Relationship of Catalysis and Active Site Loop Dynamics in the (βα)8-Barrel Enzyme Indole-3-glycerol Phosphate Synthase", Schlee, Klein, Schumacher, Nazet, Merkl, Steinhoff, Sterner, 2018

  Publikation

  It is important to understand how the catalytic activity of enzymes is related to their conformational flexibility. We have studied this...

  Publikation auf epub.uni-regensburg.de: "Relationship of Catalysis and Active Site Loop Dynamics in the (βα)8-Barrel Enzyme Indole-3-glycerol Phosphate Synthase" (externer Link, öffnet neues Fenster)

• "Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures", Linde, Heyn, Merkl, Sterner, Babinger, 2018

  Publikation

  The cell membranes of all archaea contain ether lipids, and a number of archaea are hyperthermophilic. Consequently, the enzymes that catalyze the...

  Publikation auf epub.uni-regensburg.de: "Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures" (externer Link, öffnet neues Fenster)

• "Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids", Kneuttinger, Straub, Bittner, Simeth, Bruckmann, Busch, Rajendran, Hupfeld, Wysocki, Horinek, König, Merkl, Sterner, 2019

  Publikation

  Imidazole glycerol phosphate synthase (ImGPS) is an allosteric bienzyme complex in which substrate binding to the synthase subunit HisF stimulates the...

  Publikation auf epub.uni-regensburg.de: "Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids" (externer Link, öffnet neues Fenster)

• "Mapping key amino acid residues for the epimerase efficiency and stereospecificity of the sex pheromone biosynthetic short-chain dehydrogenases/reductases of Nasonia", Semmelmann, Hofferberth, Ruther, Sterner, 2019

  Publikation

  Males of the parasitic wasp genus Nasonia use blends of chiral hydroxylactones as sex pheromones to attract conspecific females. Whereas all Nasonia...

  Publikation auf epub.uni-regensburg.de: "Mapping key amino acid residues for the epimerase efficiency and stereospecificity of the sex pheromone biosynthetic short-chain dehydrogenases/reductases of Nasonia" (externer Link, öffnet neues Fenster)

• "Library Selection with a Randomized Repertoire of (βα)8-Barrel Enzymes Results in Unexpected Induction of Gene Expression", Rohweder, Lehmann, Eichner, Polen, Rajendran, Ruperti, Linde, Treiber, Jung, Dettmer, Meister, Bott, Gronwald, Sterner, 2019

  Publikation

  The potential of the frequently encountered (beta alpha)(8)-barrel fold to acquire new functions was tested by an approach combining random...

  Publikation auf epub.uni-regensburg.de: "Library Selection with a Randomized Repertoire of (βα)8-Barrel Enzymes Results in Unexpected Induction of Gene Expression" (externer Link, öffnet neues Fenster)

• "Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology", Kneuttinger, Zwisele, Straub, Bruckmann, Busch, Kinateder, Gaim, Wysocki, Merkl, Sterner, 2019

  Publikation

  The spatiotemporal control of enzymes by light is of growing importance for industrial biocatalysis. Within this context, the photo-control of...

  Publikation auf epub.uni-regensburg.de: "Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology" (externer Link, öffnet neues Fenster)

• "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases", Semmelmann, Hupfeld, Heizinger, Merkl, Sterner, 2019

  Publikation

  The members of the glutamine amidotransferase (GATase) family catalyze the incorporation of ammonia within numerous metabolic pathways and can be...

  Publikation auf epub.uni-regensburg.de: "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases" (externer Link, öffnet neues Fenster)

• "Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction", Schupfner, Straub, Busch, Merkl, Sterner, 2019

  Publikation

  Tryptophan synthase (TS) is a heterotetrameric alpha beta beta alpha complex. It is characterized by the channeling of the reaction intermediate...

  Publikation auf epub.uni-regensburg.de: "Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction" (externer Link, öffnet neues Fenster)

• "Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint", Schupfner, Busch, Wysocki, Sterner, 2019

  Publikation

  The alpha beta beta alpha tryptophan synthase (TS), which is part of primary metabolism, is a paradigm for allosteric communication in multienzyme...

  Publikation auf epub.uni-regensburg.de: "Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint" (externer Link, öffnet neues Fenster)