Suche

Suchergebnisse

• "Structural features correlated with the extreme thermostability of 1[4Fe-4S] ferredoxin from the hyperthermophilic bacterium Thermotoga maritima.", Macedo-Ribeiro, Darimont, Sterner, 1997

  Publikation

  Understanding the molecular mechanisms behind extreme temperature stability is of relevance for the protein folding problem and for designing proteins...

  Publikation auf epub.uni-regensburg.de: "Structural features correlated with the extreme thermostability of 1[4Fe-4S] ferredoxin from the hyperthermophilic bacterium Thermotoga maritima." (externer Link, öffnet neues Fenster)

• "Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site", List, Vega, Razeto, Häger, Sterner, Wilmanns, 2012

  Publikation

  Nitrogen is incorporated into various metabolites by multifunctional glutamine amidotransferases via reactive ammonia generated by glutaminase...

  Publikation auf epub.uni-regensburg.de: "Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site" (externer Link, öffnet neues Fenster)

• "Constitutively Active Glutaminase Variants Provide Insights into the Activation Mechanism of Anthranilate Synthase", List, Bocola, Haeger, Sterner, 2012

  Publikation

  The glutamine amidotransferase (GATase) family comprises enzyme complexes which consist of glutaminase and synthase subunits that catalyze in a...

  Publikation auf epub.uni-regensburg.de: "Constitutively Active Glutaminase Variants Provide Insights into the Activation Mechanism of Anthranilate Synthase" (externer Link, öffnet neues Fenster)

• "Directed evolution of ( )8-barrel enzymes: establishing phosphoribosylanthranilate isomerisation activity on the scaffold of the tryptophan synthase -subunit", Evran, Telefoncu, Sterner, 2012

  Publikation

  Phosphoribosylanthranilate (PRA) isomerase (TrpF) and tryptophan synthase -subunit (TrpA) are ()(8)-barrel enzymes that are involved in the...

  Publikation auf epub.uni-regensburg.de: "Directed evolution of ( )8-barrel enzymes: establishing phosphoribosylanthranilate isomerisation activity on the scaffold of the tryptophan synthase -subunit" (externer Link, öffnet neues Fenster)

• "Random mutagenesis suggests that sequence errors are not a major cause of variation in the activity of individual molecules of β-galactosidase", Craig, Schwab, Sterner, 2012

  Publikation

  Wild-type Escherichia coli lacZ was subjected to error-prone PCR to generate two plasmid-encoded gene libraries containing approximately 2.6 (SD 1.9)...

  Publikation auf epub.uni-regensburg.de: "Random mutagenesis suggests that sequence errors are not a major cause of variation in the activity of individual molecules of β-galactosidase" (externer Link, öffnet neues Fenster)

• "Kinetic Mechanism of Indole-3-glycerol Phosphate Synthase", Schlee, Dietrich, Kurćon, Delaney, Goodey, Sterner, 2013

  Publikation

  The (beta alpha)(8)-barrel enzyme indole-3-glycerol phosphate synthase (IGPS) catalyzes the multistep transformation of...

  Publikation auf epub.uni-regensburg.de: "Kinetic Mechanism of Indole-3-glycerol Phosphate Synthase" (externer Link, öffnet neues Fenster)

• "Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template", Meier, Rajendran, Malisi, Fox, Xu, Schlee, Barondeau, Höcker, Sterner, Raushel, 2013

  Publikation

  Rapid evolution of enzymes provides unique molecular insights into the remarkable adaptability of proteins and helps to elucidate the relationship...

  Publikation auf epub.uni-regensburg.de: "Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template" (externer Link, öffnet neues Fenster)

• "Evidence for the Existence of Elaborate Enzyme Complexes in the Paleoarchean Era", Reisinger, Sperl, Holinski, Schmid, Rajendran, Carstensen, Schlee, Blanquart, Merkl, Sterner, 2014

  Publikation

  Due to the lack of macromolecular fossils, the enzymatic repertoire of extinct species has remained largely unknown to date. In an attempt to solve...

  Publikation auf epub.uni-regensburg.de: "Evidence for the Existence of Elaborate Enzyme Complexes in the Paleoarchean Era" (externer Link, öffnet neues Fenster)

• "Exploiting Protein Symmetry To Design Light-Controllable Enzyme Inhibitors", Reisinger, Kuzmanovic, Löffler, Merkl, König, Sterner, 2014

  Publikation

  The activity of the metabolic branch-point enzyme PriA from Mycobacterium tuberculosis (mtPriA) can be controlled reversibly by light. Two-pronged...

  Publikation auf epub.uni-regensburg.de: "Exploiting Protein Symmetry To Design Light-Controllable Enzyme Inhibitors" (externer Link, öffnet neues Fenster)

• "A common evolutionary origin of two elementary enzyme folds.", Höcker, Schmidt, Sterner, 2002

  Publikation

  The (beta alpha)(8)-barrel is the most frequent and most versatile fold among enzymes [Höcker et al., Curr. Opin. Biotechnol. 12 (2001) 376-381;...

  Publikation auf epub.uni-regensburg.de: "A common evolutionary origin of two elementary enzyme folds." (externer Link, öffnet neues Fenster)