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• "A naturally occurring standalone TrpB enzyme provides insights into allosteric communication within tryptophan synthase", Kinateder, Drexler, Duran, Osuna, Sterner, 2025

  Publikation

  Allosteric regulation of catalytic activity is a widespread property of multi-enzyme complexes. The tryptophan synthase is a prototypical allosteric...

  Publikation auf epub.uni-regensburg.de: "A naturally occurring standalone TrpB enzyme provides insights into allosteric communication within tryptophan synthase" (externer Link, öffnet neues Fenster)

• "Photoswitching of Feedback Inhibition by Tryptophan in Anthranilate Synthase", Bhagat, Schlee, Straub, Nazet, Luckner, Bruckmann, Sterner, 2022

  Publikation

  The artificial regulation of enzymatic activity by light is an important goal of synthetic biology that can be achieved by the incorporation of...

  Publikation auf epub.uni-regensburg.de: "Photoswitching of Feedback Inhibition by Tryptophan in Anthranilate Synthase" (externer Link, öffnet neues Fenster)

• "Experimental and computational analysis of the ancestry of an evolutionary young enzyme from histidine biosynthesis", Kinateder, Drexler, Straub, Merkl, Sterner, 2022

  Publikation

  The conservation of fold and chemistry of the enzymes associated with histidine biosynthesis suggests that this pathway evolved prior to the...

  Publikation auf epub.uni-regensburg.de: "Experimental and computational analysis of the ancestry of an evolutionary young enzyme from histidine biosynthesis" (externer Link, öffnet neues Fenster)

• "Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli", Busch, Rajendran, Sterner, 2023

  Publikation

  We present a detailed structure-function analysis of the ureidoacrylate amidohydrolase RutB from Eschericha coli, which is an essential enzyme of the...

  Publikation auf epub.uni-regensburg.de: "Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli" (externer Link, öffnet neues Fenster)

• "Retracing the Rapid Evolution of an Herbicide-Degrading Enzyme by Protein Engineering", Busch, Drexler, Mahato, Hiefinger, Osuna, Sterner, 2023

  Publikation

  The mechanisms underlying the rapid evolution of novel enzymatic activities from promiscuous side activities are poorly understood. Recently emerged...

  Publikation auf epub.uni-regensburg.de: "Retracing the Rapid Evolution of an Herbicide-Degrading Enzyme by Protein Engineering" (externer Link, öffnet neues Fenster)

• "Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids", Kneuttinger, Straub, Bittner, Simeth, Bruckmann, Busch, Rajendran, Hupfeld, Wysocki, Horinek, König, Merkl, Sterner, 2019

  Publikation

  Imidazole glycerol phosphate synthase (ImGPS) is an allosteric bienzyme complex in which substrate binding to the synthase subunit HisF stimulates the...

  Publikation auf epub.uni-regensburg.de: "Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids" (externer Link, öffnet neues Fenster)

• "Mapping key amino acid residues for the epimerase efficiency and stereospecificity of the sex pheromone biosynthetic short-chain dehydrogenases/reductases of Nasonia", Semmelmann, Hofferberth, Ruther, Sterner, 2019

  Publikation

  Males of the parasitic wasp genus Nasonia use blends of chiral hydroxylactones as sex pheromones to attract conspecific females. Whereas all Nasonia...

  Publikation auf epub.uni-regensburg.de: "Mapping key amino acid residues for the epimerase efficiency and stereospecificity of the sex pheromone biosynthetic short-chain dehydrogenases/reductases of Nasonia" (externer Link, öffnet neues Fenster)

• "Library Selection with a Randomized Repertoire of (βα)8-Barrel Enzymes Results in Unexpected Induction of Gene Expression", Rohweder, Lehmann, Eichner, Polen, Rajendran, Ruperti, Linde, Treiber, Jung, Dettmer, Meister, Bott, Gronwald, Sterner, 2019

  Publikation

  The potential of the frequently encountered (beta alpha)(8)-barrel fold to acquire new functions was tested by an approach combining random...

  Publikation auf epub.uni-regensburg.de: "Library Selection with a Randomized Repertoire of (βα)8-Barrel Enzymes Results in Unexpected Induction of Gene Expression" (externer Link, öffnet neues Fenster)

• "Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology", Kneuttinger, Zwisele, Straub, Bruckmann, Busch, Kinateder, Gaim, Wysocki, Merkl, Sterner, 2019

  Publikation

  The spatiotemporal control of enzymes by light is of growing importance for industrial biocatalysis. Within this context, the photo-control of...

  Publikation auf epub.uni-regensburg.de: "Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology" (externer Link, öffnet neues Fenster)

• "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases", Semmelmann, Hupfeld, Heizinger, Merkl, Sterner, 2019

  Publikation

  The members of the glutamine amidotransferase (GATase) family catalyze the incorporation of ammonia within numerous metabolic pathways and can be...

  Publikation auf epub.uni-regensburg.de: "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases" (externer Link, öffnet neues Fenster)