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• "Mapping the Allosteric Communication Network of Aminodeoxychorismate Synthase", Semmelmann, Straub, Nazet, Rajendran, Merkl, Sterner, 2019

  Publikation

  Allosteric communication between different subunits in metabolic enzyme complexes is of utmost physiological importance but only understood for few...

  Publikation auf epub.uni-regensburg.de: "Mapping the Allosteric Communication Network of Aminodeoxychorismate Synthase" (externer Link, öffnet neues Fenster)

• "Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia", Semmelmann, Kabeya, Malcicka, Bruckmann, Broschwitz, Straub, Merkl, Monroig, Sterner, Ruther, Ellers, 2019

  Publikation

  Insect pheromones are often derived from fatty acid metabolism. Fatty acid desaturases, enzymes introducing double bonds into fatty acids, are crucial...

  Publikation auf epub.uni-regensburg.de: "Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia" (externer Link, öffnet neues Fenster)

• "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases", Semmelmann, Hupfeld, Heizinger, Merkl, Sterner, 2019

  Publikation

  The members of the glutamine amidotransferase (GATase) family catalyze the incorporation of ammonia within numerous metabolic pathways and can be...

  Publikation auf epub.uni-regensburg.de: "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases" (externer Link, öffnet neues Fenster)

• "Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction", Schupfner, Straub, Busch, Merkl, Sterner, 2019

  Publikation

  Tryptophan synthase (TS) is a heterotetrameric alpha beta beta alpha complex. It is characterized by the channeling of the reaction intermediate...

  Publikation auf epub.uni-regensburg.de: "Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction" (externer Link, öffnet neues Fenster)

• "Evolutionary diversification of protein–protein interactions by interface add-ons", Plach, Semmelmann, Busch, Busch, Heizinger, Wysocki, Merkl, Sterner, 2017

  Publikation

  Cells contain amultitude of protein complexes whose subunits interact with high specificity. However, the number of different protein folds and...

  Publikation auf epub.uni-regensburg.de: "Evolutionary diversification of protein–protein interactions by interface add-ons" (externer Link, öffnet neues Fenster)

• "Combining ancestral sequence reconstruction with protein design to identify an interface hotspot in a key metabolic enzyme complex", Holinski, Heyn, Merkl, Sterner, 2017

  Publikation

  It is important to identify hotspot residues that determine protein-protein interactions in interfaces of macromolecular complexes. We have applied a...

  Publikation auf epub.uni-regensburg.de: "Combining ancestral sequence reconstruction with protein design to identify an interface hotspot in a key metabolic enzyme complex" (externer Link, öffnet neues Fenster)

• "Diversity of bacteria and archaea from two shallow marine hydrothermal vents from Vulcano Island", Antranikian, Suleiman, Schäfers, Adams, Bartolucci, Blamey, Birkeland, Bonch-Osmolovskaya, da Costa, Cowan, Danson, Forterre, Kelly, Ishino, Littlechild, Moracci, Noll, Oshima, Robb, Rossi, Santos, Schönheit, Sterner, Thauer, Thomm, Wiegel, Stetter, 2017

  Publikation

  To obtain new insights into community compositions of hyperthermophilic microorganisms, defined as having optimal growth temperatures of 80 degrees C...

  Publikation auf epub.uni-regensburg.de: "Diversity of bacteria and archaea from two shallow marine hydrothermal vents from Vulcano Island" (externer Link, öffnet neues Fenster)

• "Rosetta:MSF: a modular framework for multi-state computational protein design", Merkl, Löffler, Schmitz, Hupfeld, Sterner, 2017

  Publikation

  Computational protein design (CPD) is a powerful technique to engineer existing proteins or to design novel ones that display desired properties....

  Publikation auf epub.uni-regensburg.de: "Rosetta:MSF: a modular framework for multi-state computational protein design" (externer Link, öffnet neues Fenster)

• "Relationship of Catalysis and Active Site Loop Dynamics in the (βα)8-Barrel Enzyme Indole-3-glycerol Phosphate Synthase", Schlee, Klein, Schumacher, Nazet, Merkl, Steinhoff, Sterner, 2018

  Publikation

  It is important to understand how the catalytic activity of enzymes is related to their conformational flexibility. We have studied this...

  Publikation auf epub.uni-regensburg.de: "Relationship of Catalysis and Active Site Loop Dynamics in the (βα)8-Barrel Enzyme Indole-3-glycerol Phosphate Synthase" (externer Link, öffnet neues Fenster)

• "Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures", Linde, Heyn, Merkl, Sterner, Babinger, 2018

  Publikation

  The cell membranes of all archaea contain ether lipids, and a number of archaea are hyperthermophilic. Consequently, the enzymes that catalyze the...

  Publikation auf epub.uni-regensburg.de: "Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures" (externer Link, öffnet neues Fenster)