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• "Towards Photochromic Azobenzene‐Based Inhibitors for Tryptophan Synthase", Simeth, Kinateder, Rajendran, Nazet, Merkl, Sterner, König, Kneuttinger, 2020

  Publikation

  Light regulation of drug molecules has gained growing interest in biochemical and pharmacological research in recent years. In addition, a serious...

  Publikation auf epub.uni-regensburg.de: "Towards Photochromic Azobenzene‐Based Inhibitors for Tryptophan Synthase" (externer Link, öffnet neues Fenster)

• "In Silico Identification and Experimental Validation of Distal Activity-Enhancing Mutations in Tryptophan Synthase", Maria-Solano, Kinateder, Iglesias-Fernández, Sterner, Osuna, 2021

  Publikation

  Allostery is a central mechanism for the regulation of multi-enzyme complexes. The mechanistic basis that drives allosteric regulation is poorly...

  Publikation auf epub.uni-regensburg.de: "In Silico Identification and Experimental Validation of Distal Activity-Enhancing Mutations in Tryptophan Synthase" (externer Link, öffnet neues Fenster)

• "Reprogramming the Specificity of a Protein Interface by Computational and Data-Driven Design", Hertle, Nazet, Semmelmann, Schlee, Funke, Merkl, Sterner, 2021

  Publikation

  The formation of specific protein complexes in a cell is a non-trivial problem given the co-existence of thousands of different polypeptide chains. A...

  Publikation auf epub.uni-regensburg.de: "Reprogramming the Specificity of a Protein Interface by Computational and Data-Driven Design" (externer Link, öffnet neues Fenster)

• "Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex", Wurm, Sung, Kneuttinger, Hupfeld, Sterner, Wilmanns, Sprangers, 2021

  Publikation

  Imidazole glycerol phosphate synthase (HisFH) is a heterodimeric bienzyme complex operating at a central branch point of metabolism. HisFH is...

  Publikation auf epub.uni-regensburg.de: "Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex" (externer Link, öffnet neues Fenster)

• "Photoswitching of Feedback Inhibition by Tryptophan in Anthranilate Synthase", Bhagat, Schlee, Straub, Nazet, Luckner, Bruckmann, Sterner, 2022

  Publikation

  The artificial regulation of enzymatic activity by light is an important goal of synthetic biology that can be achieved by the incorporation of...

  Publikation auf epub.uni-regensburg.de: "Photoswitching of Feedback Inhibition by Tryptophan in Anthranilate Synthase" (externer Link, öffnet neues Fenster)

• "Experimental and computational analysis of the ancestry of an evolutionary young enzyme from histidine biosynthesis", Kinateder, Drexler, Straub, Merkl, Sterner, 2022

  Publikation

  The conservation of fold and chemistry of the enzymes associated with histidine biosynthesis suggests that this pathway evolved prior to the...

  Publikation auf epub.uni-regensburg.de: "Experimental and computational analysis of the ancestry of an evolutionary young enzyme from histidine biosynthesis" (externer Link, öffnet neues Fenster)

• "Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli", Busch, Rajendran, Sterner, 2023

  Publikation

  We present a detailed structure-function analysis of the ureidoacrylate amidohydrolase RutB from Eschericha coli, which is an essential enzyme of the...

  Publikation auf epub.uni-regensburg.de: "Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli" (externer Link, öffnet neues Fenster)

• "Retracing the Rapid Evolution of an Herbicide-Degrading Enzyme by Protein Engineering", Busch, Drexler, Mahato, Hiefinger, Osuna, Sterner, 2023

  Publikation

  The mechanisms underlying the rapid evolution of novel enzymatic activities from promiscuous side activities are poorly understood. Recently emerged...

  Publikation auf epub.uni-regensburg.de: "Retracing the Rapid Evolution of an Herbicide-Degrading Enzyme by Protein Engineering" (externer Link, öffnet neues Fenster)

• "Improving enzyme functional annotation by integrating in vitro and in silico approaches: The example of histidinol phosphate phosphatases", Kinateder, Mayer, Nazet, Sterner, 2024

  Publikation

  Advances in sequencing technologies have led to a rapid growth of public protein sequence databases, whereby the fraction of proteins with...

  Publikation auf epub.uni-regensburg.de: "Improving enzyme functional annotation by integrating in vitro and in silico approaches: The example of histidinol phosphate phosphatases" (externer Link, öffnet neues Fenster)

• "Conformational Modulation of a Mobile Loop Controls Catalysis in the (βα)8-Barrel Enzyme of Histidine Biosynthesis HisF", Hupfeld, Schlee, Wurm, Rajendran, Yehorova, Vos, Ravindra Raju, Kamerlin, Sprangers, Sterner, 2024

  Publikation

  The overall significance of loop motions for enzymatic activity is generally accepted. However, it has largely remained unclear whether and how such...

  Publikation auf epub.uni-regensburg.de: "Conformational Modulation of a Mobile Loop Controls Catalysis in the (βα)8-Barrel Enzyme of Histidine Biosynthesis HisF" (externer Link, öffnet neues Fenster)