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• "Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures", Linde, Heyn, Merkl, Sterner, Babinger, 2018

  Publikation

  The cell membranes of all archaea contain ether lipids, and a number of archaea are hyperthermophilic. Consequently, the enzymes that catalyze the...

  Publikation auf epub.uni-regensburg.de: "Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures" (externer Link, öffnet neues Fenster)

• "Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand", Kneuttinger, Winter, Simeth, Heyn, Merkl, König, Sterner, 2018

  Publikation

  The artificial regulation of proteins by light is an emerging subdiscipline of synthetic biology. Here, we used this concept to photocontrol both...

  Publikation auf epub.uni-regensburg.de: "Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand" (externer Link, öffnet neues Fenster)

• "Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole", Fleming, Schupfner, Busch, Baslé, Ehrmann, Sterner, Mayans, 2018

  Publikation

  Tryptophan synthase (TrpS) is a heterotetrameric alpha beta beta alpha enzyme that exhibits complex substrate channeling and allosteric mechanisms and...

  Publikation auf epub.uni-regensburg.de: "Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole" (externer Link, öffnet neues Fenster)

• "Mapping the Allosteric Communication Network of Aminodeoxychorismate Synthase", Semmelmann, Straub, Nazet, Rajendran, Merkl, Sterner, 2019

  Publikation

  Allosteric communication between different subunits in metabolic enzyme complexes is of utmost physiological importance but only understood for few...

  Publikation auf epub.uni-regensburg.de: "Mapping the Allosteric Communication Network of Aminodeoxychorismate Synthase" (externer Link, öffnet neues Fenster)

• "Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia", Semmelmann, Kabeya, Malcicka, Bruckmann, Broschwitz, Straub, Merkl, Monroig, Sterner, Ruther, Ellers, 2019

  Publikation

  Insect pheromones are often derived from fatty acid metabolism. Fatty acid desaturases, enzymes introducing double bonds into fatty acids, are crucial...

  Publikation auf epub.uni-regensburg.de: "Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia" (externer Link, öffnet neues Fenster)

• "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases", Semmelmann, Hupfeld, Heizinger, Merkl, Sterner, 2019

  Publikation

  The members of the glutamine amidotransferase (GATase) family catalyze the incorporation of ammonia within numerous metabolic pathways and can be...

  Publikation auf epub.uni-regensburg.de: "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases" (externer Link, öffnet neues Fenster)

• "Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction", Schupfner, Straub, Busch, Merkl, Sterner, 2019

  Publikation

  Tryptophan synthase (TS) is a heterotetrameric alpha beta beta alpha complex. It is characterized by the channeling of the reaction intermediate...

  Publikation auf epub.uni-regensburg.de: "Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction" (externer Link, öffnet neues Fenster)

• "Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint", Schupfner, Busch, Wysocki, Sterner, 2019

  Publikation

  The alpha beta beta alpha tryptophan synthase (TS), which is part of primary metabolism, is a paradigm for allosteric communication in multienzyme...

  Publikation auf epub.uni-regensburg.de: "Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint" (externer Link, öffnet neues Fenster)

• "Prediction of quaternary structure by analysis of hot spot residues in protein‐protein interfaces: the case of anthranilate phosphoribosyltransferases", Schlee, Straub, Schwab, Kinateder, Merkl, Sterner, 2019

  Publikation

  It is an important goal of computational biology to correctly predict the association state of a protein based on its amino acid sequence and the...

  Publikation auf epub.uni-regensburg.de: "Prediction of quaternary structure by analysis of hot spot residues in protein‐protein interfaces: the case of anthranilate phosphoribosyltransferases" (externer Link, öffnet neues Fenster)

• "Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids", Kneuttinger, Straub, Bittner, Simeth, Bruckmann, Busch, Rajendran, Hupfeld, Wysocki, Horinek, König, Merkl, Sterner, 2019

  Publikation

  Imidazole glycerol phosphate synthase (ImGPS) is an allosteric bienzyme complex in which substrate binding to the synthase subunit HisF stimulates the...

  Publikation auf epub.uni-regensburg.de: "Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids" (externer Link, öffnet neues Fenster)